BREATH METHANE PRODUCTION IN CHILDREN WITH CONSTIPATION AND ENCOPRESIS
BREATH METHANE PRODUCTION IN CHILDREN WITH CONSTIPATION AND ENCOPRESIS
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DOI：
10.1097/00005176-199005000-00010
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发表时间：
1990-05-01
影响因子：
2.9
通讯作者：
CASTEEL, HB
中科院分区：
文献类型：
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作者：
FIEDOREK, SC;PUMPHREY, CL;CASTEEL, HB
与成人相比，儿童呼吸中的甲烷排泄并不常见。然而，某些结肠内条件与甲烷生成增强有关。我们假设便秘和便秘的儿童，他们有异常的结肠运输时间，比健康儿童更有可能排泄甲烷。为了确定便秘或单纯性便秘患儿的甲烷排泄情况，我们对这类患者以及年龄、种族和性别匹配的对照组进行了呼吸甲烷分析。enoppretic患者（平均年龄，8.3 +-）。3.0岁)每日排便不自主，有便秘的临床证据。便秘患者(平均年龄7.1 +-。2.9年)有硬便病史并至少有下列症状之一；排便不勤、排便困难、便血、排便困难或排便时腹痛。40例梅毒患者中有26例（65%）存在甲烷排泄，而40例对照患者中有6例（15%）存在甲烷排泄（P < 0.001）。相比之下，27例便秘患者中有3例（11%）是甲烷排泄者，而对照组27例中有2例（7%）是甲烷排泄者（P = 0.4）。14例无症状感染患者治疗成功后进行复检；其中8人最初是甲烷排泄者，但其中5人在处理后不排泄甲烷。我们的结论是，甲烷在大量的隐尿症患儿体内产生。治疗似乎改变了这类患者的甲烷生成。便秘儿童中甲烷产生者的患病率与健康受试者中的患病率没有什么不同。粪尿症患者的甲烷生成可能因结肠运输时间延长或结肠内异常情况而增强。
Breath methane excretion is uncommon in children compared with adults. Certain intracolonic conditions, however, have been associated with enhanced methane generation. We hypothesized that encopretic and constipated children, who have abnormal colonic transit times, more likely would excrete methane than healthy children. To determine the prevalence of methane excretion among children with encopresis or simple constipation, we performed breath methane analysis on such patients and age-, race-, and sex-matched control subjects. Encopretic patients (mean age, 8.3 .+-. 3.0 years) had daily, involuntary passage of feces and clinical evidence of constipation. Constipated patients (mean age, 7.1 .+-. 2.9 years) had a history of hard stools and at least one of the following symptoms; infrequent defecation, dyschezia, hematochezia, difficult stool expulsion, or abdominal pain during bowel movements. Methane excretion was present in 26 of 40 (65%) encopretic patients versus 6 of 40 (15%) control patients (P < 0.001). In contrast, 3 of 27 (11%) constipated patients were methane excreters, versus 2 of 27 (7%) controls (P = 0.4). Fourteen asymptomatic encopretic patients were retested after successful therapy; eight were methane excreters initially, but five of eight did not excrete methane after treatment. We conclude that methane is produced in a large number of children with encopresis. Treatment appears to alter methanogenesis in such patients. The prevalence of methane producers among constipated children is not different from the prevalence in healthy subjects. Methanogenesis in encopretic patients may be enhanced by prolonged colonic transit time or abnormal intracolonic conditions.