Effects of tramadol on minimum alveolar concentration (MAC) of isoflurane in rats
Effects of tramadol on minimum alveolar concentration (MAC) of isoflurane in rats
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DOI：
10.1093/bja/83.5.780
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发表时间：
1999-11-01
影响因子：
9.8
通讯作者：
Wouters, PF
中科院分区：
文献类型：
--
作者：
de Wolff, MH;Leather, HA;Wouters, PF
以前曾有人提出，曲马多增加中枢神经系统的活动，并“减轻”挥发性药物的麻醉。我们评估了曲马多对56只Wistar大鼠异氟醚最低肺泡浓度（MAC）的影响，用动脉和中心静脉导管长期记录。用夹尾法测定三种情况下异氟醚的MAC：（1）注射生理盐水（对照）后，（2）静脉注射曲马多10 mg kg（-1）后，（3）静注曲马多10 mg kg（-1）后，（4）静注曲马多10 mg kg（-1）后，（5）静注曲马多10 mg kg（-1）后，（6）静注曲马多10 mg kg（-1）后，（7）静注曲马多10 mg kg（-1）后，（8）静注曲马多10 mg kg（-1）后。静注吗啡1 mg·kg ~（-1）后，再用拮抗剂纳洛酮或育亨宾治疗，曲马多和吗啡均使异氟醚的MAC由平均1.38（SEM0.05）%分别降至1.22（0.06）%和1.17（0.06）%（P
It has been suggested previously that tramadol increases central nervous system activity and 'lightens' anaesthesia with volatile agents. We assessed the effects of tramadol on the minimum alveolar concentration (MAC) of isoflurane in 56 Wistar rats, instrumented chronically with an arterial and central venous catheter. The MAC of isoflurane was determined using the tail clamp method under three conditions: (1) after injection of saline (control); (2) after administration of tramadol 10 mg kg(-1) i.v.; and (3) after administration of morphine 1 mg kg(-1) i.v. The studies were repeated after treatment with the antagonists naloxone or yohimbine, Tramadol and morphine both reduced the MAC of isoflurane from mean 1.38 (SEM 0.05)% to 1.22 (0.06)% and 1.17 (0.06)%, respectively (P