Palladium-Catalyzed Incorporation of Two C1 Building Blocks: The Reaction of Atmospheric CO2 and Isocyanides with 2-Iodoanilines Leading to the Synthesis of Quinazoline-2,4(1H,3H)-diones
Palladium-Catalyzed Incorporation of Two C1 Building Blocks: The Reaction of Atmospheric CO2 and Isocyanides with 2-Iodoanilines Leading to the Synthesis of Quinazoline-2,4(1H,3H)-diones
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钯催化两种 C1 结构单元的结合：大气 CO2 和异氰化物与 2-碘苯胺的反应导致喹唑啉-2,4(1H,3H)-二酮的合成
DOI：
10.1021/acs.orglett.7b01877
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发表时间：
2017
期刊：
影响因子：
5.2
通讯作者：
Ji Shun Jun
中科院分区：
文献类型：
--
作者：
Xu Pei;Wang Fei;Wei Tian Qi;Yin Ling;Wang Shun Yi;Ji Shun Jun
在Pd催化下，CO2和异氰化物在常压下与2-碘苯胺发生插入和环加成反应，在温和条件下生成新的C-C、C-O和C-N键，得到喹唑啉-2，4（1H，3 H）-二酮。该反应不仅为喹唑啉-2，4（1H，3 H）-二酮的合成提供了一种新的、实用的方法，而且为二氧化碳的有效利用提供了一种新的途径。
A Pd-catalyzed insertion and cycloaddition of CO2and isocyanide into 2-iodoanilines under atmospheric pressure has been developed and affords quinazoline-2,4(1H,3H)-diones through the formation of new C–C, C–O, and C–N bonds under mild conditions. This reaction provides a new and practical method not only for the construction of quinazoline-2,4(1H,3H)-diones but also for the efficient utilization of carbon dioxide.