Linear mesostructures in DNA--nanorod self-assembly.
Linear mesostructures in DNA--nanorod self-assembly.
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DOI：
10.1021/nn401413b
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发表时间：
2013-05
期刊：
影响因子：
17.1
通讯作者：
S. Vial;D. Nykypanchuk;K. Yager;A. Tkachenko;O. Gang
中科院分区：
文献类型：
--
作者：
S. Vial;D. Nykypanchuk;K. Yager;A. Tkachenko;O. Gang
分子和纳米级物体组装成一维（1D）结构，如纤维、管和带，通常是各向异性相互作用的结果。相反，我们发现一维结构可以通过一种非常不同的机制出现，即在结构形成过程中，底层粒子间相互作用的自发对称性破缺。对于含有DNA修饰的纳米级棒的系统，这种机制由柔性DNA链驱动，导致形成一维阶梯状中尺度带，具有并排的棒排列。利用电子显微镜和原位小角x射线散射（SAXS）进行详细的结构研究，以及组装动力学分析，揭示了集体DNA相互作用在线性结构形成中的作用。此外，DNA结合的可逆性随着时间的推移促进了分层组装的发展。我们还观察到类似的交替棒和球体的线性结构，这意味着所发现的机制对于通过柔性多连接器相互作用的纳米级物体是通用的。
The assembly of molecules and nanoscale objects into one-dimensional (1D) structures, such as fibers, tubules, and ribbons, typically results from anisotropic interactions of the constituents. Conversely, we found that a 1D structure can emerge via a very different mechanism, viz, the spontaneous symmetry breaking of underlying interparticle interactions during structure formation. For systems containing DNA-decorated nanoscale rods, this mechanism, driven by flexible DNA chains, results in the formation of 1D ladderlike mesoscale ribbons with a side-by-side rod arrangement. Detailed structural studies using electron microscopy and in situ small-angle X-ray scattering (SAXS), as well as analysis of assembly kinetics, reveal the role of collective DNA interactions in the formation of the linear structures. Moreover, the reversibility of DNA binding facilitates the development of hierarchical assemblies with time. We also observed similar linear structures of alternating rods and spheres, which implies that the discovered mechanism is generic for nanoscale objects interacting via flexible multiple linkers.