Insecticidal resistance of Culex tritaeniorhynchus (Diptera: Culicidae) in Japan: genetics and mechanisms of resistance to organophosphorus insecticides.
Insecticidal resistance of Culex tritaeniorhynchus (Diptera: Culicidae) in Japan: genetics and mechanisms of resistance to organophosphorus insecticides.
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日本三带喙库蚊（双翅目：库蚊科）的杀虫剂抗性：对有机磷杀虫剂的遗传学和抗性机制。
DOI：
10.1093/jmedent/24.6.595
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发表时间：
1987
影响因子：
2.1
通讯作者：
K. Yasutomi
中科院分区：
文献类型：
--
作者：
M. Takahashi;K. Yasutomi
日本三带喙库蚊富山品系对有机磷杀虫剂具有高度抗性。对替美磷、马拉硫磷、杀螟松和倍硫磷的抗药性比率分别超过125，000、6，000、26，500和22，929。抗性不完全占易感性的主导地位。乙酰胆碱酯酶对化合物的不敏感性是耐药的主要因素。对氧磷的不敏感指数为734，与标准敏感（台湾）菌株相比。也有证据表明羧酸酯酶具有解毒作用。两个羧酸酯酶基因和一个编码乙酰胆碱酯酶主要分子种类的基因都位于染色体II上。当富山菌株与易感标记突变体杂交而不发生染色体重组时，这些多个酶因子共同作用，表明在染色体II上有一个抗性基因。
The Toyama strain of Culex tritaeniorhynchus Giles collected and colonized in Japan was highly resistant to organophosphorus insecticides. Resistance ratios were more than 125,000 for temephos, 6,000 for malathion, 26,500 for fenitrothion, and 22,929 for fenthion. Resistance was incompletely dominant over susceptibility. Insensitivity of acetylcholinesterase to the compounds was the major factor of resistance. The insensitivity index for paraoxon was 734 in comparison with a standard susceptible (Taiwan) strain. There was also evidence for detoxification by carboxylesterase. Two carboxylesterase genes and one gene coding a major molecular species of acetylcholinesterase were all located on chromosome II. These multiple enzymatic factors acted together, indicating a single gene for resistance on chromosome II, when the Toyama strain was crossed with susceptible marker mutants without recombination of the chromosome.