Measurement of coordination of object manipulation in non-human primates
Measurement of coordination of object manipulation in non-human primates
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DOI：
10.1016/j.jneumeth.2005.11.013
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发表时间：
2006-06-30
影响因子：
3
通讯作者：
Morecraft, RJ
中科院分区：
文献类型：
--
作者：
Darling, WG;Peterson, CR;Morecraft, RJ
我们提出了对自动运动评估面板的修改[Gash DM、Zhang Z、Umberger G、Mahood K、Smith M、Smith C 等人。用于恒河猴和人类上肢运动功能的自动运动评估面板。 J NeurosciMethods 1999;89:111-7]，它结合了一个三维测力传感器来记录猴子在操纵食物目标时施加的力。绝对力-时间积分（总绝对冲量）用于表征随着时间的推移，当食物（中心有一个孔的胡萝卜片）被操纵并从平坦表面提起（最简单的任务）并穿过直杆（中等难度）或弯曲杆（最高难度）时所施加的力的总和。即使尝试获取食物失败，也可以测量总冲动。因此，即使在成功习得之前，它也可以用来评估表现的变化，例如神经系统损伤后的学习或恢复。我们通过三只恒河猴的测试表明，总绝对脉冲测量对任务复杂性、学习和额叶运动区损伤（在一种情况下）敏感，并且在猴子学会任务后，日常表现（即使表现之间的时间间隔很长）具有良好的可靠性。重要的是，这项任务需要最少的训练，因为猴子只需一两次训练就可以成功完成这些任务中最困难的任务，但在几次测试中，性能仍然会不断提高。此外，任务难度的三个级别允许分析能力的进展。 (c) 2005 Elsevier B.V. 保留所有权利。
We present a modification of the automated movement assessment panel [Gash DM, Zhang Z, Umberger G, Mahood K, Smith M, Smith C, et al. An automated movement assessment panel for upper limb motor functions in rhesus monkeys and humans. J Neurosci Methods 1999;89:111-7] that incorporates a three-dimensional load cell to record forces applied by monkeys while manipulating food targets. The absolute force-time integral (total absolute impulse) is used to characterize the total of the applied forces over time as the food (carrot chip with a hole punched through the center) is manipulated and lifted from a flat surface (easiest task) and threaded over a straight rod (medium difficulty) or curved rod (highest difficulty). The total impulse can be measured even on unsuccessful attempts to acquire the food. Thus, it can be used to evaluate changes in performance even before successful acquisition occurs as in learning or recovery following a nervous system insult. We show from tests in three rhesus monkeys that the total absolute impulse measure is sensitive to task complexity, learning and lesion of frontal lobe motor areas (in one case) and that there is good reliability in day-to-day performance (even with long periods between performances) after the monkey has learned the task. Importantly, the task requires minimal training as the monkeys can be successful on even the most difficult of these tasks with one or two training sessions, yet performance improvements continue to occur over several testing sessions. Furthermore, the three levels of task difficulty permit analysis of a progression of ability. (c) 2005 Elsevier B.V. All rights reserved.