Systemic sclerosis mortality in the United States: 1979-1998
Systemic sclerosis mortality in the United States: 1979-1998
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DOI：
10.1007/s10654-005-2210-5
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发表时间：
2005-10-01
影响因子：
13.6
通讯作者：
Furst, DE
中科院分区：
文献类型：
--
作者：
Krishnan, E;Furst, DE
自1979年以来，美国全国系统性硬化症(SSC)的死亡率一直没有报道。我们使用Poisson回归模型研究了1979-1998年间美国全国SSc死亡率的年龄、性别和种族时间趋势。在本研究所述期间的49.3亿人年观察期间，有18126人死于珊瑚礁，死亡率为3.9‰。男性和女性的年龄调整死亡率分别为1.9‰和5.4‰。在极端年龄阶段，死亡人数相对较少。在性别和所有种族群体中，SSc死亡率都随着年龄的增长而增加(p<；0.001)。在对双向统计交互作用进行调整的多变量模型中，非裔美国人、女性和年龄较大的人与更高的死亡率相关。在20年的观察中，总体(年龄调整后)SSC死亡率上升了36%(p<；0.001)，亚组分析显示，上升仅限于两个种族的女性。这一上升发生在已知的SSc诊断后存活率增加的时期，这表明这种疾病的发病率正在增加。
The US national mortality rates from systemic sclerosis (SSc) have not been reported since 1979. We studied age, gender and race specific time trends in US national mortality rates of SSc during the period 1979-1998 using poisson regression models. Over the 4.93 billion person-years of observation during the study period, there were 18,126 deaths from SSc, representing a mortality rate of 3.9 per million. The age adjusted mortality rates for men and women were 1.9 and 5.4 per million respectively. There were relatively few deaths in the extremes of age. SSc mortality rates increased with age in both genders and in all racial groups (p < 0.001). In multivariable models adjusted for two-way statistical interactions, being African-American, female and of older age were associated with higher death rates. Over the 20 years of observation, overall (age-adjusted) SSc mortality rates showed a 36% increase (p < 0.001) and subgroup analyses revealed that the increases were confined to women of both races. This rise occurred during a period in which post-diagnosis survival of SSc is known to have increased, suggesting an increasing incidence of this disease.