Effect of Plasma Fibrinogen Concentration on the Inhibition of Platelet Aggregation After Ticlopidine Compared With Aspirin
Effect of Plasma Fibrinogen Concentration on the Inhibition of Platelet Aggregation After Ticlopidine Compared With Aspirin
复制标题
噻氯匹定与阿司匹林相比血浆纤维蛋白原浓度对抑制血小板聚集的影响
作者：
H. Tohgi;Hiroaki Takahashi;M. Kashiwaya;Katsumi Watanabe
血浆纤维蛋白原水平升高是脑梗死的危险因素。由于纤维蛋白原在血小板聚集中起核心作用，而噻氯匹定可抑制纤维蛋白原与血小板的结合，因此我们研究了血浆纤维蛋白原浓度对噻氯匹定与阿司匹林抗聚集作用的影响。方法对61例脑卒中患者应用噻氯匹定（200 mg/d）或阿司匹林（81 mg/d）前后的血小板聚集性进行测定，并将其与血浆纤维蛋白原浓度的变化进行相关性分析。结果噻氯匹定治疗后，1、5、10 μmol/L二磷酸腺苷诱导的血小板聚集性较用药前显著降低（P< 0.05），且与血浆纤维蛋白原浓度呈显著负相关（P< 0.05）。2 μmol/ mL胶原和5、10 μmol/L二磷酸腺苷诱导的血小板聚集性较用药前降低（P< 0.005），但与血浆纤维蛋白原浓度无显著相关性。结论随着血浆纤维蛋白原浓度的升高，噻氯匹定的相对抗聚集作用明显减弱。这可以解释，至少部分地，个体对噻氯匹定反应的差异。
Elevated levels of plasma fibrinogen are a risk factor for cerebral infarction. Because fibrinogen plays a central role in platelet aggregation and binding of fibrinogen to platelets is inhibited by ticlopidine, we studied the effect of the plasma fibrinogen concentration on the antiaggregatory action of ticlopidine compared with that of aspirin. Methods We determined platelet aggregability before and after administration of ticlopidine (200 mg/d) or aspirin (81 mg/d) in 61 stroke patients and correlated the changes with the plasma fibrinogen concentration. Results In patients receiving ticlopidine, the platelet aggregability induced by 1, 5, and 10 μmol/L adenosine diphosphate significantly decreased compared with aggregability before medication (P<.05), and the reductions had significant negative correlations with the plasma fibrinogen concentration (P<.05). In patients receiving aspirin, the platelet aggregability induced by 2 μg/mL collagen and 5 and 10 μmol/L adenosine diphosphate decreased compared with aggregability before medication (P<.005), but the reductions had no significant correlation with the plasma fibrinogen concentration. Conclusions The relative antiaggregatory effect of ticlopidine is significantly decreased with higher plasma fibrinogen concentrations. This may explain, at least in part, the individual variation in the response to ticlopidine.
胰凝乳蛋白酶和二磷酸腺苷对正常人和血小板无力症血小板上纤维蛋白原受体暴露的影响。
DOI：
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发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Kornecki,E;Niewiarowski,S;Morinelli,TA;Kloczewiak,M
通讯作者：
Kloczewiak,M
影响因子：
20.3
作者：
G. Minno;P. Thiagarajan;B. Perussia;J. Martínez;S. Shapiro;G. Trinchieri;S. Murphy
通讯作者：
G. Minno;P. Thiagarajan;B. Perussia;J. Martínez;S. Shapiro;G. Trinchieri;S. Murphy