Study of Serum CD147 Level in Patients with Transient Ischemic Attack and CD147 Expression in Atherosclerotic Plaque
Study of Serum CD147 Level in Patients with Transient Ischemic Attack and CD147 Expression in Atherosclerotic Plaque
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短暂性脑缺血发作患者血清CD147水平及动脉粥样硬化斑块中CD147表达的研究
DOI：
10.1007/s12265-018-9817-x
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发表时间：
2018-08-01
影响因子：
3.4
通讯作者：
Cen, Shan
中科院分区：
文献类型：
--
作者：
Xu, Bin;Wu, Chan;Cen, Shan
越来越多的证据强调CD147在动脉粥样硬化中的潜在作用，但CD147在短暂性脑缺血发作（TIA）和急性脑梗死（ACI）的诊断和治疗中的潜在意义仍不清楚。在这项工作中，我们研究了 TIA 和 ACI 患者的血清 CD147 水平以及动脉粥样硬化斑块中的 CD147 表达。结果显示，TIA和ACI患者血清CD147水平显着升高，易损斑块中CD147含量较迁移斑块增加。 CD147 的血清水平与 TIA 发作后发生卒中的风险相关。这些结果共同表明 CD147 可能参与 TIA 和 ACI 的发生和进展，并且 CD147 作为卒中预测的潜在生物标志物。
There is growing evidence that highlighted the potential effects of CD147 in atherosclerosis, but the potential implication of CD147 in diagnosis and treatment of transient ischemic attack (TIA) and acute cerebral infarction (ACI) is still unclear. In this work, we investigated the serum level of CD147 in patients with TIA and ACI, and CD147 expression in atherosclerotic plaque. The result showed significantly increasing serum level of CD147 in patients with TIA and ACI, and increasing amount of CD147 in vulnerable plaque compared with that in migrating plaque. The serum level of CD147 was correlation with risk of stroke after an episode of TIA. These results together suggest a potential involvement of CD147 in the development and progression of TIA and ACI and CD147 as a potential biomarker for stroke prediction.