Anti-tumour clerodane-type diterpenes from Mitrephora thorelii
Anti-tumour clerodane-type diterpenes from Mitrephora thorelii
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DOI：
10.1080/10286020601103270
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发表时间：
2007-01-01
影响因子：
1.7
通讯作者：
Zhao, Wei-Min
中科院分区：
文献类型：
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作者：
Meng, Da-Hai;Xu, Yong-Ping;Zhao, Wei-Min
通过生物测定指导对 Mitrephora thorelii（番荔枝科）粗提物进行分馏，分离出两种 clerodane 型二萜。基于光谱方法将其结构表征为6α,16,18-三羟基cleroda-3(4),13(14)-dien-15,16-olide (1)和16-羟基cleroda-3(4),13(14)-dien-15,16-olide (2)。化合物1是一个新化合物。化合物1和2在体外对人肝癌BEL-7402细胞的增殖表现出抑制活性。化合物 2 还显示出对小鼠肝癌 H22 生长的体内抗肿瘤作用。
Bioassay-guided fractionation of the crude extract of Mitrephora thorelii (Annonaceae) led to the isolation of two clerodane-type diterpenes. Their structures were characterised on the basis of spectroscopic methods as 6 alpha,16,18-trihydroxycleroda-3(4),13(14)-dien-15,16-olide (1) and 16-hydroxycleroda-3(4),13(14)-dien-15,16-olide (2). Compound 1 is a new compound. Compounds 1 and 2 exhibited inhibitory activity against the proliferation of human hepatoma BEL-7402 cells in vitro. Compound 2 also showed an in vivo anti-tumour effect against the growth of hepatoma H22 in mice.