The pathogenesis of duck virus enteritis in experimentally infected ducks: a quantitative time-course study using TaqMan polymerase chain reaction
The pathogenesis of duck virus enteritis in experimentally infected ducks: a quantitative time-course study using TaqMan polymerase chain reaction
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鸭病毒性肠炎在实验感染鸭中的发病机制：利用 TaqMan 聚合酶链反应进行的定量时程研究
DOI：
10.1080/03079450802043775
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发表时间：
2008-01-01
期刊：
影响因子：
2.8
通讯作者：
Jia Renyong
中科院分区：
文献类型：
--
作者：
Qi Xuefeng;Yang Xiaoyan;Jia Renyong
鸭病毒性肠炎是鸭、鹅和天鹅的一种急性、传染性疱疹病毒感染，具有高发病率和高死亡率。研究了强毒鸭肠炎病毒的病毒DNA载量动力学、免疫组化定位以及鸭经口感染后各组织的组织病理学检查。各组织中病毒抗原出现和组织病变的时间进程与不同部位的鸭肠炎病毒水平一致，这表明全身器官中鸭肠炎病毒的水平与疾病进展密切相关。靶向上皮细胞和淋巴细胞的丰富程度可能有助于病毒在淋巴组织和肠道组织中的高水平感染和复制。
Duck virus enteritis is an acute and contagious herpesvirus infection of duck, geese and swans with high morbidity and mortality. The kinetics of viral DNA loads and immunohistochemical localization of virulent duck enteritis virus, as well as histopathological examination in various tissues of ducks following oral infection, were investigated. The time course for the appearance of viral antigen and tissue lesions in various tissues was coincident with the levels of duck enteritis virus at the various sites, suggesting that the levels of duck enteritis virus in systemic organs have a close correlation with the progression of disease. The abundance of target epithelial and lymphoid cells may contribute to the high levels of virus infection and replication in lymphoid and intestinal tissues.