Connecting combat-related mild traumatic brain injury with posttraumatic stress disorder symptoms through brain imaging
Connecting combat-related mild traumatic brain injury with posttraumatic stress disorder symptoms through brain imaging
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DOI：
10.1016/j.neulet.2014.05.054
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发表时间：
2014-08-08
影响因子：
2.5
通讯作者：
Roy, Michael J.
中科院分区：
文献类型：
--
作者：
Costanzo, Michelle E.;Chou, Yi-Yu;Roy, Michael J.
轻度创伤性脑损伤（mTBI）和创伤后应激障碍（PTSD）可能在部署后的军事服务人员（SM）中共享共同的症状和神经心理学特征;虽然这两种情况之间的联系似乎是合理的，但它们之间的关系一直难以辨别。本报告的目的是提高我们对结构和功能脑成像结果与PTSD症状之间关系的理解。在一组不符合PTSD标准但愿意在从战斗部署返回后2个月内完成全面评估的SM中，我们进行了嵌套病例对照分析，将与战斗相关的mTBI与年龄/性别匹配的对照进行了扩散张量成像，静息状态功能磁共振成像和一系列心理测量。我们报告退化的白色物质的完整性，在那些有历史的战斗mTBI，和正相关的白色物质的微观结构和默认模式网络（DMN）的连接。较高的临床医生管理和自我报告的阈下PTSD症状的报告与战斗mTBI。我们的研究结果提供了一种潜在的机制，通过这种机制，mTBI可能会改变大脑功能，从而导致PTSD症状。出版社：Elsevier爱尔兰Ltd.
Mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) may share common symptom and neuropsychological profiles in military service members (SMs) following deployment; while a connection between the two conditions is plausible, the relationship between them has been difficult to discern. The intent of this report is to enhance our understanding of the relationship between findings on structural and functional brain imaging and symptoms of PTSD. Within a cohort of SMs who did not meet criteria for PTSD but were willing to complete a comprehensive assessment within 2 months of their return from combat deployment, we conducted a nested case-control analysis comparing those with combat-related mTBI to age/gender-matched controls with diffusion tensor imaging, resting state functional magnetic resonance imaging and a range of psychological measures. We report degraded white matter integrity in those with a history of combat mTBI, and a positive correlation between the white matter microstructure and default mode network (DMN) connectivity. Higher clinician-administered and self-reported subthreshold PTSD symptoms were reported in those with combat mTBI. Our findings offer a potential mechanism through which mTBI may alter brain function, and in turn, Contribute to PTSD symptoms. Published by Elsevier Ireland Ltd.