Nutrient intake and risk of non-Hodgkin's lymphoma
Nutrient intake and risk of non-Hodgkin's lymphoma
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DOI：
10.1093/aje/kwj330
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发表时间：
2006-12-15
影响因子：
5
通讯作者：
Adami, Hans-Olov
中科院分区：
文献类型：
--
作者：
Chang, Ellen T.;Balter, Katarina M.;Adami, Hans-Olov
饮食可能影响非霍奇金淋巴瘤（NHL）发展的机制尚不清楚，但通过检查营养摄入与NHL风险之间的关系可以更好地理解。2000年至2002年间，瑞典591例NHL病例和460例以人群为基础的对照者完成了半定量食物频率问卷调查。采用无条件逻辑回归来估计与营养摄入相关的比值比和95%置信区间；所有统计检验均为双侧检验。大多数宏量营养素的饮食摄入与NHL或其常见亚型的风险无关。食用omega-3或海洋脂肪酸与NHL和慢性淋巴细胞淋巴瘤的风险降低有关，膳食纤维与所有亚型的风险降低有关。比较海洋脂肪摄入量最高和最低四分位数时，NHL风险的优势比为0.6(95%可信区间：0.4,0.9),p（趋势）= 0.03；对于膳食纤维摄入量，相应的比值比为0.5(95%可信区间：0.3,0.7),p（趋势）< 0.001。饮食中摄入β -胡萝卜素或α -生育酚与较低的NHL风险相关，而摄入钙或视黄醇与NHL风险增加相关。影响炎症、维生素D活性、DNA氧化损伤或DNA甲基化的营养物质可能与NHL的风险相关。
The mechanisms through which diet may influence the development of non-Hodgkin's lymphoma (NHL) are unclear but can be better understood by examining associations between nutrient consumption and NHL risk. Between 2000 and 2002, 591 NHL cases and 460 population-based controls in Sweden completed a semiquantitative food frequency questionnaire. Unconditional logistic regression was performed to estimate odds ratios and 95% confidence intervals for associations with nutrient intake; all statistical tests were two sided. Dietary intake of most macronutrients was not associated with risk of NHL or its common subtypes. Consumption of omega-3 or marine fatty acids was associated with decreased risk of NHL and chronic lymphocytic lymphoma, and dietary fiber was associated with lower risk of all subtypes examined. When the highest and the lowest quartiles of marine fat intake were compared, the odds ratio for NHL risk was 0.6 (95% confidence interval: 0.4, 0.9), p(trend) = 0.03; for dietary fiber intake, the corresponding odds ratio was 0.5 (95% confidence interval: 0.3, 0.7), p(trend) < 0.001. Dietary consumption of beta-carotene or alpha-tocopherol was associated with lower NHL risk, whereas intake of calcium or retinol was associated with increased NHL risk. Nutrients that affect inflammation, vitamin D activity, oxidative DNA damage, or DNA methylation may be associated with risk of NHL.