Investigation of OPET performance using GATE, a Geant4-based simulation software
Investigation of OPET performance using GATE, a Geant4-based simulation software
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DOI：
10.1109/tns.2004.835737
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发表时间：
2004-10-01
影响因子：
1.8
通讯作者：
Chatziioannou, AF
中科院分区：
文献类型：
--
作者：
Rannou, FR;Kohli, V;Chatziioannou, AF
组合光学正电子发射断层扫描（OPET）系统能够在同一设置下同时进行光学和PET成像，并且它可以提供单模成像无法提供的信息/解释。这里的闪烁体阵列具有双重功能，即耦合来自生物发光/荧光的光信号到光电探测器，并引导来自伽马射线的光学闪烁。我们报告了使用Geant4仿真包GATE对OPET的PET部分的仿真结果。本研究的目的是定义OPET层析成像的几何参数。OPET由6个探测器块组成，其内半径为15.6 mm，呈六角形环状排列。每个探测器由8 × 8个闪烁晶体组成的二维阵列，每个晶体的尺寸为2 × 2 × 10mm(3)。使用GATE软件进行蒙特卡罗模拟，测量两种环构型，有和没有龙门旋转，两种晶体材料和几种晶体长度的绝对灵敏度，相互作用深度和空间分辨率。对正弦图进行角交织和横向一维插值后，用滤波后的反向投影重建图像。我们报告的绝对灵敏度几乎是原型微pet在视场中心的7倍，切向分辨率为2.0 mm，径向分辨率为2.3 mm，龙门旋转高达8.0 mm径向偏移。这些性能参数表明，OPET系统的成像空间分辨率和灵敏度将适用于高分辨率和高灵敏度的小动物PET成像。
A combined optical positron emission tomography (OPET) system is capable of both optical and PET imaging in the same setting, and it can provide information/interpretation not possible in single-mode imaging. The scintillator array here serves the dual function of coupling the optical signal from bioluminescence/fluorescence to the photodetector and also of channeling optical scintillations from the gamma rays. We report simulation results of the PET part of OPET using GATE, a Geant4 simulation package. The purpose of this investigation is the definition of the geometric parameters of the OPET tomograph. OPET is composed of six detector blocks arranged in a hexagonal ring-shaped pattern with an inner radius of 15.6 mm. Each detector consists of a two-dimensional array of 8 x 8 scintillator crystals each measuring 2 x 2 x 10 mm(3). Monte Carlo simulations were performed using the GATE software to measure absolute sensitivity, depth of interaction, and spatial resolution for two ring configurations, with and without gantry rotations, two crystal materials, and several crystal lengths. Images were reconstructed with filtered backprojection after angular interleaving and transverse one-dimensional interpolation of the sinogram. We report absolute sensitivities nearly seven times that of the prototype microPET at the center of field of view and 2.0 mm tangential and 2.3 mm radial resolutions with gantry rotations up to an 8.0 mm radial offset. These performance parameters indicate that the imaging spatial resolution and sensitivity of the OPET system will be suitable for high-resolution and high-sensitivity small-animal PET imaging.