Fibrin fibers have extraordinary extensibility and elasticity
Fibrin fibers have extraordinary extensibility and elasticity
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DOI：
10.1126/science.1127317
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发表时间：
2006-08-04
期刊：
影响因子：
56.9
通讯作者：
Guthold, M.
中科院分区：
文献类型：
--
作者：
Liu, W.;Jawerth, L. M.;Guthold, M.
血凝块执行一项基本的机械任务，然而形成血凝块结构框架的纤维蛋白纤维的机械行为在很大程度上是未知的。通过联合原子力-荧光显微镜，我们确定了单个纤维的弹性极限和延伸性。纤维蛋白纤维可拉伸180%（延长2.8倍）而不保持永久延长，在断裂前可拉伸525%（平均330%）。这是观察到的蛋白质纤维最大的延展性。这些数据表明，纤维蛋白单体必须能够经历相当大的、可逆的结构变化，并且凝块中的变形可以通过单个纤维拉伸来调节。
Blood clots perform an essential mechanical task, yet the mechanical behavior of fibrin fibers, which form the structural framework of a clot, is largely unknown. By using combined atomic force‐fluorescence microscopy, we determined the elastic limit and extensibility of individual fibers. Fibrin fibers can be strained 180% (2.8-fold extension) without sustaining permanent lengthening, and they can be strained up to 525% (average 330%) before rupturing. This is the largest extensibility observed for protein fibers. The data imply that fibrin monomers must be able to undergo sizeable, reversible structural changes and that deformations in clots can be accommodated by individual fiber stretching.