Neural stem cells in the adult human brain
Neural stem cells in the adult human brain
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DOI：
10.1006/excr.1999.4678
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发表时间：
1999-12-15
影响因子：
3.7
通讯作者：
Frisén, J
中科院分区：
文献类型：
--
作者：
Johansson, CB;Svensson, M;Frisén, J
成人大脑的某些区域不断产生新的神经元。对啮齿动物的研究表明，新的神经元是由自我更新的多能神经干细胞产生的。在这里，我们证明成人大脑的侧脑室壁和海马体都含有能够在体外产生神经元、星形胶质细胞和少突胶质细胞的自我更新细胞，即真正的神经干细胞。 (C) 1999 年学术出版社。
New neurons are continuously generated in certain regions of the adult brain. Studies in rodents have shown that new neurons are generated from self-renewing multipotent neural stem cells. Here we demonstrate that both the lateral ventricle wall and the hippocampus of the adult human brain harbor self-renewing cells capable of generating neurons, astrocytes, and oligodendrocytes in vitro, i.e., bona fide neural stem cells. (C) 1999 Academic Press.