Treatment of terminal leukemic relapse by total-body irradiation and intravenous infusion of stored autologous bone marrow obtained during remission.
Treatment of terminal leukemic relapse by total-body irradiation and intravenous infusion of stored autologous bone marrow obtained during remission.
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通过全身照射和静脉输注缓解期间获得的储存自体骨髓来治疗晚期白血病复发。
DOI：
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发表时间：
1959
影响因子：
158.5
通讯作者：
Webster Ew
中科院分区：
文献类型：
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作者：
J. McGovern;P. Russell;L. Atkins;Webster Ew
在其中一种化疗药物诱导的儿童急性白血病缓解期间，骨髓可能暂时恢复正常形态状态。因此，问题是，在某些情况下，骨髓是否可以提供可接受的自体材料来源，以便随后用作自体骨髓移植。1据报道，在动物体内输入自体骨髓2 3 4，在人体内输入同种骨髓，5在潜在致命剂量的放射或化疗药物后，6可以通过恢复骨髓细胞数量来保护其免受其他致命影响。也有研究表明，骨髓可以被保存下来。
DURING a remission of acute leukemia in children induced by one of the chemotherapeutic agents the bone marrow may return temporarily to a normal morphologic state. Thus, the question arises whether in some cases the marrow may provide an acceptable source of autologous material for subsequent use as a marrow autograft.1 It has been reported that the infusion of autologous marrow in animals2 3 4 and isologous marrow in man,5 after potentially lethal doses of radiation or chemotherapeutic agents,6 can protect against their otherwise lethal effects by restoring the marrow cell population. It has also been shown that marrow may be preserved . . .