Human vertebral body apparent and hard tissue stiffness
Human vertebral body apparent and hard tissue stiffness
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DOI：
10.1016/s0021-9290(98)00110-9
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发表时间：
1998-11-01
影响因子：
2.4
通讯作者：
Fyhrie, DP
中科院分区：
文献类型：
--
作者：
Hou, FJ;Lang, SM;Fyhrie, DP
松质骨的表观刚度和强度取决于组织水平和小梁结构的材料特性。使用微观结构精确的大型有限元 (LS-FE) 模型来预测人体椎体松质骨的实验表观刚度并估计小梁硬组织刚度。直接从微型计算机断层扫描图像生成 28 个圆柱形人体椎体松质骨样本（直径 8 毫米，高 9.5 毫米，每个来自 28 个个体）的 LS-FE 模型，并通过专用迭代有限元程序进行求解。样品的实验表观刚度和强度是通过上下方向失效的机械测试来确定的。还计算了形态测量，包括骨体积分数 (BV/TV)、织物张量的三个特征值和平均 P-L。表观刚度的有限元估计解释了实验表观刚度 (r(2) = 0.89) 和实验表观强度 (r(2) = 0.87) 的大部分方差。逐步线性回归分析表明，当 LS-FE 估计表观刚度包含在所有测量的形态测量值中时，它是实验表观刚度和强度的唯一重要预测因子。个体之间的硬组织硬度差异很大（平均值为 5.7 GPa；标准差为 1.6 GPa），但与该样本的年龄、性别、种族、体重或形态测量值没有显着相关。 (C) 1998 年由爱思唯尔科学有限公司出版。保留所有权利。
Cancellous bone apparent stiffness and strength are dependent upon material properties at the tissue level and trabecular architecture. Microstructurally accurate, large-scale finite element (LS-FE) models were used to predict the experimental apparent stiffness of human vertebral cancellous bone and to estimate the trabecular hard tissue stiffness. Twenty-eight LS-FE models of cylindrical human vertebral cancellous bone specimens (8 mm in diameter, 9.5 mm in height, one each from twenty-eight individuals) were generated directly From microcomputed tomography images and solved by a special purpose iterative finite element program. The experimental apparent stiffness and strength of the specimens were determined by mechanical testing to failure in the infero-superior direction. Morphometric measurements including bone volume fraction (BV/TV), three eigenvalues of the fabric tensor and average P-L were also calculated. The finite element estimate of apparent stiffness explained much of the variance in both experimental apparent stiffness (r(2) = 0.89) and experimental apparent strength (r(2) = 0.87), Stepwise linear regression analysis demonstrated that the LS-FE estimated apparent stiffness was the only significant predictor of experimental apparent stiffness and strength when it was included with all measured morphometric values. Hard tissue stiffness was quite variable between individuals (mean, 5.7 GPa; S.D. 1.6 GPa), but was not significantly related to age, sex, race, weight or morphometric measures for this sample. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.