Squamous cell cancer of the nasal cavity: New insights and implications for diagnosis and treatment
Squamous cell cancer of the nasal cavity: New insights and implications for diagnosis and treatment
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DOI：
10.1002/hed.24391
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发表时间：
2016-04-01
影响因子：
2.9
通讯作者：
Pfeiffer, Jens
中科院分区：
文献类型：
--
作者：
Becker, Christoph;Kayser, Gian;Pfeiffer, Jens
背景。鼻腔鳞状细胞癌（SCC）是一种罕见的恶性肿瘤，经常与鼻或鼻窦的其他肿瘤在异质性研究中进行分析。本研究的目的是评估鼻腔SCC中不同的危险因素、肿瘤特征、结局预测因素和人乳头瘤病毒（HPV）的患病率。我们进行了一项回顾性研究，39例患者在单一的四级医疗保健和癌症中心接受治疗。我们分析了肿瘤特征、HPV状态、治疗和结果。我们报告了单一中心对鼻腔鳞状细胞癌的最大研究。大多数患者（70.2%）表现为早期肿瘤（T1或T2）。只有1例患者在诊断时有单一颈部转移。4个肿瘤hpv阳性。大多数患者（61.5%）在没有辅助治疗的情况下接受了手术切除，12例患者（30.8%）接受了额外的放疗。3例患者接受了原发性放疗或放化疗。以全鼻切除术为主的患者无局部肿瘤复发。局部肿瘤控制是至关重要的，即使需要进行根治性手术。术后矫形治疗使随访检查可靠。诊断时的区域转移是罕见的。因此，对于怀疑有转移的病例，应保留颈部清扫术。HPV也可能在鼻腔SCC的病因学中起作用。(C) 2016 Wiley期刊公司
Background. Squamous cell carcinoma (SCC) of the nasal cavity is a rare malignancy and often analyzed in heterogeneous studies with other tumors of the nose or the paranasal sinuses. The purpose of this study was to evaluate distinct risk factors, tumor characteristics, outcome predictors, and the prevalence of human papillomavirus (HPV) in SCC of the nasal cavity.Methods. We conducted a retrospective study of 39 patients treated at a single quaternary medical care and cancer center. We analyzed tumor characteristics, HPV status, treatment, and outcome. We present the largest study on SCC of the nasal cavity from a single center.Results. The majority of patients (70.2%) presented with an early-stage tumor (T1 or T2). Only 1 patient had a single neck metastasis at the time of diagnosis. Four tumors were HPV-positive. Most patients (61.5%) underwent surgical resection without adjuvant treatment, with 12 patients (30.8%) undergoing additional radiotherapy. Three patients were treated with primary radiotherapy or chemoradiotherapy. No patient treated primarily with total rhinectomy developed local tumor recurrence.Conclusion. Local tumor control is crucial, even if it makes radical surgery necessary. Postoperative epithetic treatment enables reliable follow-up examinations. Regional metastases at the time of diagnosis are rare. Neck dissection should therefore be reserved for cases of suspected metastasis. HPV may also play a role in the etiology of SCC of the nasal cavity. (C) 2016 Wiley Periodicals, Inc.