Wide variation in caffeine discontinuation timing in premature infants.
Wide variation in caffeine discontinuation timing in premature infants.
复制标题
早产儿停止摄入咖啡因的时间差异很大。
DOI：
10.1038/s41372-019-0561-0
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Greenberg,RachelG
中科院分区：
文献类型：
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作者：
Ji,Dabin;Smith,PBrian;Clark,ReeseH;Zimmerman,KaneciaO;Laughon,Matthew;Ku,Lawrence;Greenberg,RachelG
目的评估与咖啡因停药时间相关的部位变异性和伴随呼吸支持，并比较在住院前和最后一周内停药的婴儿的临床特征。研究设计：对2001-2016年从304个新生儿重症监护病房出院的81110名<35周胎龄和<1500 g出生体重的婴儿进行队列研究。结果各试验点停止使用咖啡因的平均经后年龄为32 ~ 37周。停药时的呼吸支持是常见的，但有变化，0-57%的婴儿在不同部位的咖啡因停药时接受气道正压。在住院的最后一周内停用咖啡因的婴儿，咖啡因的总持续时间更长，但出院的月经后年龄更早。结论各部位在停药前停药时间和停药时的呼吸支持方面存在较大差异。
ObjectiveTo assess site variability and concomitant respiratory support related to the timing of caffeine discontinuation, and compare clinical characteristics of infants who discontinued caffeine before vs. within the last week of hospitalization.Study designCohort study of 81,110 infants <35 weeks gestational age and <1500 g birth weight discharged from 304 neonatal intensive care units from 2001–2016.ResultsThe mean postmenstrual age at caffeine discontinuation ranged from 32 to 37 weeks among sites. Respiratory support at the time of discontinuation was common, but variable, with 0–57% of infants receiving positive airway pressure at caffeine discontinuation by site. Infants who discontinued caffeine within the last week of hospitalization had longer total duration of caffeine, but were discharged from the hospital at an earlier postmenstrual age.ConclusionThere was substantial variability among sites in the timing of caffeine discontinuation before discharge and respiratory support at the time of caffeine discontinuation.