Short tandem repeat polymorphism analysis for primary peritoneal choriocarcinoma: A case report and literature review
Short tandem repeat polymorphism analysis for primary peritoneal choriocarcinoma: A case report and literature review
复制标题
原发性腹膜绒毛膜癌短串联重复多态性分析一例报告及文献复习
DOI：
10.1111/jog.15347
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发表时间：
2022
影响因子：
1.6
通讯作者：
Goto Masaki
中科院分区：
文献类型：
--
作者：
Yamauchi Kota;Sato Yukiyasu;Usui Hirokazu;Sakurai Azusa;Harada Ryusuke;Goto Masaki
腹膜是发生原发性绒毛膜癌极为罕见的部位。原发性腹膜绒毛膜癌可以是妊娠期或非妊娠期，而子宫或输卵管绒毛膜癌是直接归因于妊娠期起源。在此，我们报告一例原发性腹膜绒毛膜癌，基因诊断为妊娠亚型，起源于隐匿的完全葡萄胎。一位46岁的女性患者，有两次人工流产史，临床怀疑输卵管破裂妊娠，接受了紧急剖腹手术。剖腹探查发现左侧输卵管系膜出血肿瘤，左侧卵巢和输卵管明显完好。病理诊断为绒毛膜癌。多重短串联重复多态性分析显示为雄激素基因/纯合子基因型肿瘤，确定其起源为完整的葡萄胎。我们对9例原发性腹膜绒毛膜癌病例的文献回顾，包括我们的病例，强调了肿瘤基因分型在区分妊娠期和非妊娠期亚型以及确定病因妊娠中的重要性。
The peritoneum is an extremely rare site for primary choriocarcinoma development. Primary peritoneal choriocarcinoma could be either gestational or nongestational, whereas it is straightforward to ascribe uterine or tubal choriocarcinoma to the gestational origin. Herein, we report a case of primary peritoneal choriocarcinoma that is genetically diagnosed as a gestational subtype originating from an occult complete hydatidiform mole. A 46‐year‐old female patient with two‐time induced abortion histories underwent emergency laparotomy under clinical suspicion of ruptured tubal pregnancy. Laparotomy revealed a hemorrhagic tumor in the left mesosalpinx with apparently intact left ovary and fallopian tube. The excised tumor was pathologically diagnosed as choriocarcinoma. Multiplex short tandem repeat polymorphism analysis revealed an androgenetic/homozygous genotype tumor, identifying its origin as a complete hydatidiform mole. Our literature review of nine primary peritoneal choriocarcinoma cases, including ours, highlighted the importance of tumor genotyping in differentiating between gestational and non‐gestational subtypes and identifying the causative pregnancy.