From here to paternity: Neural correlates of the onset of paternal behavior in California mice (Peromyscus californicus)
From here to paternity: Neural correlates of the onset of paternal behavior in California mice (Peromyscus californicus)
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DOI：
10.1016/j.yhbeh.2009.05.001
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发表时间：
2009-08-01
影响因子：
3.5
通讯作者：
Saltzman, Wendy
中科院分区：
文献类型：
--
作者：
de Jong, Trynke R.;Chauke, Miyetani;Saltzman, Wendy
在包括人类在内的少数哺乳动物物种中，父亲在婴儿护理中发挥着重要作用。与母亲的行为相比，父亲照顾的神经和激素基础知之甚少。我们分析了行为，神经元和神经肽对不熟悉的幼崽在双亲加州小鼠，比较男性与另一个男性（“处女男性”）或与女性之前（“配对男性”）或之后（“新父亲”）出生的第一窝。新的父亲更迅速地接近幼崽，花更多的时间从事父亲的行为比处女男性。在每个饲养两只未交配雄性动物的笼中，一只自发为父系，另一只不是。新的父亲和配对的男性花更多的时间嗅和触摸一个金属丝网球包含一个新生的小狗比处女男性。与空球相比，只有新父亲在接触含有幼崽的球后，内侧视前核（MPO）中的Fos样免疫反应性显着增加。此外，Fos-LIR在床核的终纹（STMV和STMPM）和尾中缝背核（DRC）增加，在新的父亲，独立的测试条件。催产素能或加压素能神经元的Fos-LIR在各组间无差异。这些结果表明，性和父亲的经验促进了父亲的行为，但其他线索也发挥了作用。父亲的经验增加Fos-LIR诱导的远端小狗线索在MPO，但不是在催产素和加压素神经元。父亲身份似乎也改变了BNST和DRC的神经传递，这些区域与情绪和压力反应有关。爱思唯尔公司出版
In a minority of mammalian species, including humans, fathers play a significant role in infant care. Compared to maternal behavior, the neural and hormonal bases of paternal care are poorly understood. We analyzed behavioral, neuronal and neuropeptide responses towards unfamiliar pups in biparental California mice, comparing males housed with another male ("virgin males") or with a female before ("paired males") or after ("new fathers") the birth of their first litter. New fathers approached pups more rapidly and spent more time engaging in paternal behavior than virgin males. In each cage housing two virgin males, one was spontaneously paternal and one was not. New fathers and paired males spent more time sniffing and touching a wire mesh ball containing a newborn pup than virgin males. Only new fathers showed significantly increased Fos-like immunoreactivity in the medial preoptic nucleus (MPO) following exposure to a pup-containing ball, as compared to an empty ball. Moreover, Fos-LIR in the bed nucleus of the stria terminalis (STMV and STMPM) and caudal dorsal raphe nucleus (DRC) was increased in new fathers, independent of test condition. No differences were found among the groups in Fos-LIR in oxytocinergic or vasopressinergic neurons. These results suggest that sexual and paternal experiences facilitate paternal behavior, but other cues play a role as well. Paternal experience increases Fos-LIR induced by distal pup cues in the MPO, but not in oxytocin and vasopressin neurons. Fatherhood also appears to alter neurotransmission in the BNST and DRC, regions implicated in emotionality and stress-responsiveness. Published by Elsevier Inc.