Carotenoids, retinol and tocopherols in patients with insulin-dependent diabetes mellitus and their immediate relatives
Carotenoids, retinol and tocopherols in patients with insulin-dependent diabetes mellitus and their immediate relatives
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DOI：
10.1042/cs0940189
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发表时间：
1998-02-01
期刊：
影响因子：
6
通讯作者：
Rojas-Hidalgo, E
中科院分区：
文献类型：
--
作者：
Granado, F;Olmedilla, B;Rojas-Hidalgo, E
1.胰岛素依赖型糖尿病患者被归类为维生素水平低的风险人群，最近的研究表明，一定程度的抗氧化剂补充可能有助于预防糖尿病的某些长期并发症。我们的目的是比较脂溶性维生素和抗氧化剂相关化合物在明确定义的胰岛素依赖型糖尿病患者及其一级亲属中的状态，控制季节和分析变异性作为影响数据解释的因素。54例胰岛素依赖型糖尿病患者，214例非糖尿病一级亲属（对照组）和236名无关对照进行了分析，（α和γ）和血清中的主要类胡萝卜素（β-胡萝卜素、α-胡萝卜素、β-隐黄质、叶黄素、玉米黄质和番茄红素）。与性别匹配的一级亲属相比，胰岛素依赖型糖尿病患者的视黄醇水平较低，β-胡萝卜素、α-胡萝卜素和β-隐黄素水平较高，α-生育酚、α-生育酚/胆固醇比率、γ-生育酚、叶黄素、玉米黄质和番茄红素没有表现出差异。视黄醇和β-胡萝卜素是与糖尿病关系最密切的变量。胰岛素依赖型糖尿病患者血清视黄醇水平较低，维生素原-A类胡萝卜素浓度较高。血清脂溶性抗氧化剂水平大于或等于对照组。根据观察到的血清状态，糖尿病患者不需要补充α-生育酚或类胡萝卜素，但应评估边缘血清水平患者是否需要补充视黄醇。
1. Patients with insulin-dependent diabetes mellitus are classified among the groups at risk for low vitamin status, and recent studies suggest that some degree of supplementation with antioxidants may be beneficial in helping to prevent certain long-term complications of diabetes mellitus. Our objective was to compare the status of the fat-soluble vitamins and antioxidant-related compounds in patients with well-defined insulin-dependent diabetes mellitus with that of their first-degree relatives, controlling seasonal and analytical variability as factors influencing the interpretation of the data.2. Fifty-four patients with insulin-dependent diabetes mellitus, 214 non-diabetic, first-degree relatives (controls) and 236 unrelated controls were analysed for retinol, tocopherols (alpha and gamma) and main carotenoids in serum (beta-carotene, alpha-carotene, beta-cryptoxanthin, lutein, zeaxanthin and lycopene) by means of a validated HPLC method.3, Insulin-dependent diabetes mellitus was associated with lower retinol levels and higher levels of beta-carotene, alpha-carotene and beta-cryptoxanthin than sex-matched, first-degree relatives, alpha-Tocopherol, the alpha-tocopherol/cholesterol ratio, gamma-tocopherol, lutein, zeaxanthin and lycopene showed no differences. Retinol and beta-carotene were the variables most closely associated with diabetes.4. Patients with insulin-dependent diabetes mellitus showed lower serum retinol status together with higher concentrations of provitamin-A carotenoids. Serum fat-soluble antioxidant levels were greater than or equal to those in controls. According to the serum status observed, individuals with diabetes do not require supplementation with alpha-tocopherol or carotenoids, although the need for retinol supplementation in patients with marginal serum levels should be evaluated.