Improving stable isotopic interpretations made from human hair through reduction of growth cycle error.
Improving stable isotopic interpretations made from human hair through reduction of growth cycle error.
复制标题
通过减少生长周期误差来改善对人类头发的稳定同位素解释。
DOI：
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发表时间：
2011
影响因子：
2.8
通讯作者：
F. Longstaffe
中科院分区：
文献类型：
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作者：
L. Williams;C. White;F. Longstaffe
稳定同位素分析的最新趋势包括利用头发片段重建饮食的短期变化。然而，大量的头发样本通常含有生长周期误差，这可能会掩盖或混淆最近合并的同位素信息。假设，在任何给定的时间，~ 85-90%的头皮头发都在积极生长，而剩余的10-15%已经过渡到静止或不活跃阶段，在头发脱落之前持续长达4个月。本研究使用生长阶段来确定年龄、性别和健康状况对头发碳氮同位素比率的影响，并按顺序进行分析。在这项研究中，我们选择了来自埃及达赫勒绿洲的10个人的考古头发样本。对每个人活跃生长的头发片段的同位素分析与混合生长阶段片段的同位素分析进行了比较。这些数据证明了生长周期误差的存在，并表明对结构-功能关系的理解对于解释毛囊和纤维生成的正常与病理变化至关重要。在饮食变化和活动导致个体同位素组成变化的情况下，消除序列片段头发分析中的位置-时间误差可以促进对个体内部代谢反应和头发生长周期变化的更好理解。阶段识别可能有助于确定个体的病理状况，特别是那些缺乏骨骼指征的个体，并提供更精确的季节性饮食模式，获取变化的食物资源和新地区代谢平衡的估计。
A recent trend in stable isotopic analysis involves the reconstruction of short-term variations in diet using hair segments. However, bulk hair samples typically contain a growth cycle error, which may conceal or confound the most recently incorporated isotopic information. It is assumed that, at any given time, ∼85-90% of scalp hairs are actively growing, while the remaining 10-15% have transitioned into a resting or inactive phase, which lasts up to 4 months before hairs are shed. This study uses growth phase to determine the effects of age, sex, and health status on carbon and nitrogen isotopic ratios of hair analyzed in sequential segments. For this study, we selected archaeological hair samples from 10 individuals from Dakhleh Oasis, Egypt. Isotopic analyses of actively growing hair segments were compared to those for mixed growth phase segments from each individual. These data demonstrate the presence of growth cycle error and show that an understanding of structural-functional relationships is essential for interpreting normal versus pathological changes in hair follicle and fiber production. In situations where diet change and mobility produce variations in an individual's isotopic composition, elimination of positional-temporal error in sequential segment hair analyses can facilitate greater understanding of intraindividual metabolic reactions and changes in hair growth cycles. Phase identification may aid in determining the presence of pathological conditions in individuals, especially in those lacking skeletal indications, and provide a more precise estimation of seasonal dietary patterns, access to changing food resources, and metabolic equilibration to a new locality.
头发中罗丹明和荧光素的体内和体外沉积比较。
DOI：
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发表时间：
1998
期刊：
Drug metabolism and disposition: the biological fate of chemicals.
影响因子：
--
作者：
Stout,PR;Ruth,JA
通讯作者：
Ruth,JA