A placebo controlled randomized trial of the effects of phenylpropanolamine and nicotine gum on cessation rates and postcessation weight gain in women
A placebo controlled randomized trial of the effects of phenylpropanolamine and nicotine gum on cessation rates and postcessation weight gain in women
复制标题
DOI：
10.1016/j.addbeh.2004.04.013
复制
发表时间：
2005-01-01
影响因子：
4.4
通讯作者：
Clemens, LH
中科院分区：
文献类型：
--
作者：
Cooper, TV;Klesges, RC;Clemens, LH
随着吸烟流行率开始下降，旨在促进更具挑战性的人群（如体重相关的吸烟者）戒烟的研究值得关注。这项研究评估了两种形式的药物治疗[尼古丁和苯丙醇胺（PPA）口香糖]的疗效，以及针对女性的13周认知行为戒烟计划。参与者是439名符合严格筛选标准的女性，并被随机分配到三个治疗干预组之一（PPA口香糖，尼古丁口香糖或安慰剂口香糖）。所有参与者都参加了为期13周的认知行为戒烟计划，并得到了咀嚼口香糖的具体指导。在后测（13周），6个月和12个月的随访，体重和点患病率禁欲进行了评估。进行了分析，以确定治疗组之间在体重变化和戒烟率方面的潜在差异。结果表明，两组之间的体重变化和戒烟率均无显著差异。参加会议似乎始终增加戒烟的可能性在后测试和每次随访。这些结果表明，尽管药物干预对戒烟率和戒烟后体重增加没有影响，但干预的行为成分在增加体重相关女性戒烟的几率方面是有效的。未来的努力应该集中在增加遵守行为计划的组成部分，特别是会议出席。(C)2004爱思唯尔有限公司保留所有权利。
With smoking prevalence rates beginning to decline, studies designed to promote cessation in more challenging populations, like weight-concerned smokers, warrant attention. This study assessed the efficacy of two forms of pharmacotherapy [nicotine and phenylpropanolamine (PPA) gums] in addition to a 13-week cognitive behavioral smoking cessation program targeted for women. Participants were 439 females who met rigorous screening criteria and were randomized to one of the three treatment intervention groups (PPA gum, nicotine gum, or placebo gum). All participants attended a 13-week cognitive behavioral smoking cessation program and were given specific instructions on gum chewing. At posttest (13 weeks), and 6- and 12-month follow-ups, body weight and point prevalence abstinence were assessed. Analyses to determine potential differences between treatment groups on weight change and cessation rates were performed. Results indicated that neither change in body weight nor cessation rates significantly differed between groups. Attendance to sessions did appear to consistently increase the likelihood of quitting smoking at posttest and at each of the follow-ups. These results suggest that although the pharmacological interventions had no effect on cessation rates and postcessation weight gain, the behavioral component of the intervention was effective in increasing the odds of quitting smoking in weight-concemed women. Future efforts should focus on increasing adherence to behavioral program components, particularly session attendance. (C) 2004 Elsevier Ltd. All rights reserved.