Accuracy of day 3 criteria for selecting the best embryos
Accuracy of day 3 criteria for selecting the best embryos
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DOI：
10.1016/s0015-0282(02)03104-7
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发表时间：
2002-06-01
影响因子：
6.7
通讯作者：
Behr, B
中科院分区：
文献类型：
--
作者：
Milki, AA;Hinckley, MD;Behr, B
目的：评估第3天形态学标准在识别最佳胚胎中的准确性。设计：前瞻性观察研究。设置：大学IVF项目。患者：在第3天具有大于或等于3个8细胞胚胎的需要囊胚移植的女性的100个周期。干预：在第3天，胚胎学家选择当天移植的两个胚胎。在第5天，胚胎进行检查，以确定最好的和第二最好的blastocysts.Main Outcome Measure（S）：第3天的准确性，在第5天的培养测量，nontransferred picks的结果，和cryopreservation rate. Results（S）：所有周期达到囊胚阶段和73%的冷冻保存。平均囊胚数为4.8（第5天为3.2，第6天为1.6）。在39%的循环中没有选择任何一个纬纱;在38%的循环中转移一个纬纱;在23%的循环中转移两个纬纱。在H6非转移镐中，51个被冻结，65个被停止，两个镐在9个循环中停止。单一的最佳囊胚选择的挑选在39%的cycles. Conclusions（S）：卵裂期胚胎选择的形态学标准可能会下降不足时，转移仅限于两个胚胎。在这个群体中培养囊胚是必要的，以避免高阶倍数，并仍然能够选择两个具有最高植入潜力的胚胎。(C)2002年，美国生殖医学会。
Objective: To assess the accuracy of day 3 morphologic criteria in identifying the best embryos.Design: Prospective observational study.Setting: University IVF program.Patient(s): One hundred cycles in women desiring blastocyst transfer who had greater than or equal to3 eight-cell embryos on day 3.Intervention(s): On day 3, the embryologist chose the two embryos that would have been transferred that day. On day 5, embryos were examined to determine the best and second-best blastocysts.Main Outcome Measure(s): Accuracy of day 3 picks as measured in culture on day 5, outcome of nontransferred picks, and cryopreservation rate.Result(s): All cycles reached the blastocyst stage and 73% had cryopreservation. The mean number of blastocysts was 4.8 (3.2 on day 5 and 1.6 on day 6). Neither pick was chosen in 39% of cycles; one pick was transferred in 38%; and both picks were transferred in 23%. Of H 6 nontransferred picks, 51 were frozen and 65 arrested, with both picks arresting in 9 cycles. The single best blastocyst was chosen from the picks in 39% of cycles.Conclusion(s): Morphologic criteria for cleavage-stage embryo selection may fall short when the transfer is limited to two embryos. Culture to blastocyst is warranted in this population to avoid high-order multiples and still be able to choose the two embryos with the highest implantation potential. (C) 2002 by American Society for Reproductive Medicine.