Inhibitory effect of brachytherapy on intimal hyperplasia in arteriovenous fistula.
Inhibitory effect of brachytherapy on intimal hyperplasia in arteriovenous fistula.
复制标题
近距离放射治疗对动静脉瘘内膜增生的抑制作用。
DOI：
10.1016/s0022-4804(03)00253-1
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
S. Greenstein
中科院分区：
文献类型：
--
作者：
Shu;J. Beitler;T. Ohki;T. Calderon;R. Schechner;R. Yaparpalvi;J. Berman;V. Tellis;S. Greenstein
METHODSE要确定是否血管内辐射可以抑制内膜增生的猪模型的血液透析access.MATERIALS和METHODSPolyarteriovenous移植物（6毫米直径）之间的颈总动脉和颈外静脉两侧8只猪。术后2天，进行瘘管造影。通过使用铱192源在血管内向静脉吻合处的其中一个移植物输送伽马辐射（12戈伊）。因此，每头猪的另一个移植物作为未处理对照。放疗后6周行瘘管造影或静脉造影。所有移植物均进行组织学和免疫组化检查，治疗侧的移植物和对照侧的5个移植物均保持至少6周的通畅。血管造影显示，治疗组静脉吻合口狭窄百分比显著较低（15.9 ± 14.1% vs 32.6 ± 16.7%，P = 0.045）。组织学分析显示，与对照侧相比，治疗侧静脉吻合口的平均内膜面积和最大内膜厚度显著降低，平滑肌细胞增殖减少（分别为0.68 ± 0.30与1.06 ± 0.29 mm 2，P = 0.017; 0.18 ± 0.08与0.26 ± 0.07 mm 2，P = 0.004）。治疗组的残留管腔显著更大（1.59 ± 0.42与1.06 ± 0.37 mm 2，P = 0.031）。没有发现显着差异的面积，也没有最大厚度的静脉近端或远端的吻合两groups.CONCLUSIONSIn血液透析通路的动物模型，近距离放射治疗与铱192移植植入后2天交付减少内膜增生和狭窄的静脉吻合。在放射治疗的静脉中发现平滑肌细胞减少，表明近距离放射治疗可能通过抑制平滑肌细胞增殖对新生内膜形成产生影响。
PURPOSETo determine whether endovascular radiation can inhibit intimal hyperplasia in a swine model of hemodialysis access.MATERIALS AND METHODSPolytetrafluoroethylene arteriovenous grafts (6 mm in diameter) were placed between the common carotid artery and the external jugular vein bilaterally in 8 pigs. Two days after the surgery, fistulography was performed. Gamma radiation (12 Gy) was delivered endovascularly to one of the grafts at the venous anastomosis by using an iridium192source. Thus, the other graft in each pig served as an untreated control. Fistulas were evaluated with fistulography or venography 6 week after radiation. All grafts were then harvested for histological and immunohistochemical examination.RESULTSSeven grafts on the treated side and 5 grafts on the control side remained patent for at least 6 weeks. Angiography demonstrated that the percentage stenosis at the venous anastomosis was significantly lower for the treated group (15.9 ± 14.1 versus 32.6 ± 16.7%, P = 0.045). Histopathologic analyses revealed that the mean intimal area and maximal intimal thickness were significantly lower with reduced smooth muscle cell proliferation at the venous anastomosis on the treated side compared to the control side (0.68 ± 0.30 versus 1.06 ± 0.29 mm2, P = 0.017, and 0.18 ± 0.08 versus 0.26 ± 0.07 mm, P = 0.004, respectively). The residual lumen was significantly greater for the treated group (1.59 ± 0.42 versus 1.06 ± 0.37 mm2, P = 0.031). No significant differences were found in the area, nor maximal thickness in the vein either proximal or distal to the anastomosis between the two groups.CONCLUSIONSIn an animal model of hemodialysis access, brachytherapy with iridium192delivered 2 days after graft implantation reduces intimal hyperplasia and stenosis at the venous anastomosis. The reduced smooth-muscle cells found in the radiated veins suggests that brachytherapy may exert its effect on neointimal formation by inhibition of smooth muscle cell proliferation.
高脂血清和辐射对血管细胞原代静态培养物伤口愈合的影响。
影响因子：
3.6
作者：
Fischer-Dzoga,K;Dimitrievich,GS;Schaffner,T
通讯作者：
Schaffner,T
血管组织的放射敏感性。
影响因子：
3.4
作者：
Fischer-Dzoga,K;Dimitrievich,GS;Griem,ML
通讯作者：
Griem,ML
DOI：
10.1161/01.atv.13.4.609
发表时间：
1993-04-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
REKHTER, M;NICHOLLS, S;GORDON, D
通讯作者：
GORDON, D