VIRUCIDAL EFFECTS OF THE STEAM DISTILLATE FROM HOUTTUYNIA-CORDATA AND ITS COMPONENTS ON HSV-1, INFLUENZA-VIRUS, AND HIV
VIRUCIDAL EFFECTS OF THE STEAM DISTILLATE FROM HOUTTUYNIA-CORDATA AND ITS COMPONENTS ON HSV-1, INFLUENZA-VIRUS, AND HIV
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DOI：
10.1055/s-2006-958063
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发表时间：
1995-06-01
期刊：
影响因子：
2.7
通讯作者：
HAYASHI, T
中科院分区：
文献类型：
--
作者：
HAYASHI, K;KAMIYA, M;HAYASHI, T
从新鲜鱼腥草植物中提取的蒸汽馏出物。发现对单纯疱疹病毒1型（HSV-1）、流感病毒和人类免疫缺陷病毒1型（HIV-1）有直接抑制活性，但对脊髓灰质炎病毒和柯萨奇病毒没有细胞毒性。病毒传染性的丧失与药物治疗的持续时间有关，蒸馏物的三种主要成分，甲基n-壬基酮、十二烷基醛和癸基醛也灭活了HSV-1、流感病毒和HIV-1。这些体外实验结果表明，精油通过干扰病毒包膜的功能，对包膜病毒具有杀病毒活性。
The steam distillate prepared from fresh plants of Houttuynia cordata Thunb. (Saururaceae) was found to have direct inhibitory activity against herpes simplex virus type 1 (HSV-1), influenza virus, and human immunodeficiency virus type 1 (HIV-1) without showing cytotoxicity, but not against poliovirus and coxsackievirus. The loss of viral infectivity was related to the duration of drug treatment, Three major components of the distillate, methyl n-nonyl ketone, lauryl aldehyde, and capryl aldehyde, also inactivated HSV-1, influenza virus, and HIV-1. These in vitro findings demonstrate that the essential oils provide virucidal activity against enveloped viruses by interfering with the function of virus envelope.