Prospective study of caffeine consumption and risk of Parkinson's disease in men and women
Prospective study of caffeine consumption and risk of Parkinson's disease in men and women
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DOI：
10.1002/ana.1052
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发表时间：
2001-07-01
影响因子：
11.2
通讯作者：
Willett, WC
中科院分区：
文献类型：
--
作者：
Ascherio, A;Zhang, SMM;Willett, WC
病例对照研究和男性前瞻性调查的结果表明，喝咖啡可以预防帕金森病的风险，但活性成分并不昂贵。为了解决咖啡因对帕金森病有保护作用的假设，我们在两个正在进行的队列中，即健康专业人员随访研究（HPFS）和护士健康研究（NHS），研究了咖啡和咖啡因摄入量与这种疾病风险的关系。研究人群包括47，351名男性和88，565名女性，他们没有帕金森病，中风，或癌症。参与者在基线时完成了一份全面的生活方式和饮食问卷，并每两到四年更新一次。在接下来的唇（男性10年，女性16年），我们记录了共288例帕金森病的事件。在男性中，在调整年龄和吸烟后，与咖啡因摄入量最低的五分之一相比，咖啡因摄入量最高的五分之一的男性患帕金森病的相对风险为0.42（95% CI：0.23-0.78;趋势P < 0.001）。此外，还观察到咖啡（趋势p = 0.004）、非咖啡来源的咖啡因（趋势p < 0.001）和茶（趋势p = 0.02）的消费量呈负相关，但不包括脱咖啡因咖啡。在女性中，咖啡因或咖啡摄入量与帕金森病风险之间的关系呈U形，在中等摄入量（每天1-3杯咖啡，或咖啡因摄入量的第三个五分位数）下观察到的风险最低。这些结果支持了中等剂量咖啡因对帕金森病风险的可能保护作用。
Results of case-control studies and of a prospective investigation in men suggest that consumption of coffee could protect against the risk of Parkinson's disease, but the active constituent is not dear. To address the hypothesis that caffeine is protective against Parkinson's disease, we examined the relationship of coffee and caffeine consumption to the risk of this disease among participants in two ongoing cohorts, the Heath Professionals' Follow-Up Study (HPFS) and the Nurses' Heath Study (NHS), The study population comprised 47,351 men and 88,565 women who were free of Parkinson's disease, stroke, or cancer at baseline. A comprehensive life style and dietary questionnaire was completed by the participants at baseline and updated every two to four years. During the follow-lip (10 years in men, 16 years in women), we documented a total of 288 incident cases of Parkinson's disease. Among men, after adjustment for age and smoking, the relative risk of Parkinson's disease was 0.42 (95% CI: 0.23-0.78; P for trend < 0.001) for men in the top one-fifth of caffeine intake compared to those in the bottom one-fifth. An inverse association was also observed with consumption of coffee (p for trend = 0.004), caffeine from noncoffee sources (p for trend < 0.001), and tea (p for trend = 0.02) but not decaffeinated coffee. Among women, the relationship between caffeine or coffee intake and risk of Parkinson's disease was U-shaped, with the lowest risk observed at moderate intakes (1-3 cups of coffee/day, or the third quintile of caffeine consumption). These results support a possible protective effect of moderate doses of caffeine on risk of Parkinson's disease.