Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction
Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction
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载脂蛋白 A1 与非 ST 段抬高型心肌梗死患者的 SYNTAX 评分相关
DOI：
10.1186/s12944-019-1101-9
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发表时间：
2019-08-07
影响因子：
4.5
通讯作者：
Ma, Yi-Tong
中科院分区：
文献类型：
--
作者：
Chen, Bang-Dang;Chen, Xiao-Cui;Ma, Yi-Tong
本研究旨在调查非ST段抬高心肌梗死(NSTEMI)患者的血脂谱和句法评分。记录患者的人口学、临床数据、血样和语法评分。使用皮尔逊线性相关来检测与句法分数线性相关的混杂因素。结果皮尔逊直线相关分析显示高密度脂蛋白胆固醇、载脂蛋白A1与句法评分显著相关(r= − 0.119，P= 0.044；r= − 0.182，P= 0.002)。用高密度脂蛋白胆固醇和载脂蛋白A1分别建立句法评分的多元线性回归模型。在调整了白细胞计数、肌红蛋白、谷草转氨酶和肌酐等其他显著相关的混杂因素后，载脂蛋白A1仍与语法评分显著相关(β= − 0.151，P= 0.028)。ApoA1预测冠状动脉中重度病变的曲线下面积(AUC)为0.624，最佳临界值为1.07 g/L。载脂蛋白A1 ≥ 1.07 g/L和 <； 1.07 g/L患者的句法评分分别为12.21 ± 11.58和16.33 ± 11.53(P= 0.001)。结论载脂蛋白A1是唯一与冠状动脉病变复杂程度显著相关的血脂因素，载脂蛋白A1 ； 1.07 g/L患者可能存在更复杂的冠状动脉病变。
BackgroundThe study was designed to investigate lipid profile and SYNTAX score in patients with non-ST segment elevation myocardial infarction (NSTEMI).Methods311 patients with NSTEMI were enrolled. The demographic, clinical data, blood samples and SYNTAX score were documented. The Pearson linear correlation was used to detect confounding factors linearly correlated with SYNTAX score. The significantly correlated confounding factors were put into the multiple linear regressions.ResultsThe Pearson linear correlation showed that high-density lipoprotein- cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) were significantly correlated with Syntax Score (r= − 0.119,P= 0.044 andr= − 0.182,P= 0.002, respectively). The multiple linear regressions for Syntax Score were built using HDL-C and ApoA1, respectively. After the adjustment of other significantly correlated confounding factors such as white blood cell count (WBC), myohemoglobin (MB), glutamic-oxalacetic transaminase (AST) and creatinine, the ApoA1 still showed significant association with Syntax Score (β= − 0.151,P= 0.028). The area under curve was (AUC) 0.624 and the optimal cutoff value is 1.07 g/L when using ApoA1 to predict moderate and severe coronary artery lesions. The patients with ApoA1 ≥ 1.07 g/L and < 1.07 g/L have the Syntax Scores of 12.21 ± 11.58 and 16.33 ± 11.53, respectively (P= 0.001).ConclusionsThe ApoA1 is the only lipid factor significantly associated with complexity of coronary artery lesion in patients with NSTEMI, the patients with ApoA1 < 1.07 g/L may have more complex coronary artery lesions.