The Association of ADH and ALDH Gene Variants With Alcohol Drinking Habits and Cardiovascular Disease Risk Factors
The Association of ADH and ALDH Gene Variants With Alcohol Drinking Habits and Cardiovascular Disease Risk Factors
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DOI：
10.1111/j.1530-0277.2008.00780.x
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发表时间：
2008-11-01
影响因子：
3.2
通讯作者：
Linneberg, Allan
中科院分区：
文献类型：
--
作者：
Husemoen, Lise Lotte Nystrup;Fenger, Mogens;Linneberg, Allan
背景：酒精代谢的遗传变异可能影响饮酒习惯和饮酒对健康影响的易感性。在饮酒对健康影响的流行病学研究中，这种影响可能会使暴露与疾病之间的联系产生偏差。在高加索人群中，我们研究了酒精脱氢酶(ADH)和乙醛脱氢酶(ALDH)基因变异与饮酒习惯、酒精暴露的生物标志物和心血管疾病风险因素的关系。方法：研究人群包括1,216名年龄在15-77岁的丹麦男性和女性，他们在1998年参加了一次健康检查。健康检查包括自填式调查问卷(饮酒习惯)、体检(血压)和各种血液检查[丙氨酸氨基转移酶(ALAT)、红细胞平均体积(E-MCV)和血脂]。用标准技术检测ADH和ALDH基因变异体。结果：自我报告饮酒与ALAT、E-MCV、高密度脂蛋白胆固醇和血压水平升高显著相关。ALDH1bala69val变异与不饮酒和总饮酒有关。ALDH2启动子区变异与酗酒有关，ALDH1b1ala69val多态与舒张压相关。结论：在这个高加索人群样本中，我们发现了支持酒精代谢遗传变异可能影响饮酒习惯的证据，但没有统计上显著的基因-环境交互作用。需要更多的大规模流行病学研究来证实这些结果，并进一步调查饮酒影响的遗传易感性。
Background: Genetic variation in ethanol metabolism may have an influence on both alcohol drinking habits and the susceptibility to health effects of alcohol drinking. Such influences are likely to bias exposure-disease associations in epidemiologic studies of health effects of alcohol drinking. In a Caucasian population, we examined the association of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genetic variants with alcohol drinking habits, biomarkers of alcohol exposure, and risk factors for cardiovascular disease.Methods: The study population consisted of 1,216 Danish men and women aged 15-77 years participating in a health examination in 1998. The health examination included a self-administered questionnaire (alcohol drinking habits), a physical examination (blood pressure), and various blood tests [alanine aminotransferase (ALAT), erythrocyte mean corpuscular volume (E-MCV), and lipids]. ADH and ALDH gene variants were determined by standard techniques. Data were analyzed by regression analyses adjusted for relevant confounders.Results: Self-reported alcohol drinking was significantly associated with increasing levels of ALAT, E-MCV, high-density lipoprotein cholesterol, and blood pressure. The ALDH1b ala69val variant was associated with nondrinking and total alcohol intake. The ALDH2 promoter variant was associated with binge-drinking, and the ALDH1b1 ala69val polymorphism was associated with diastolic blood pressure. We did not find any statistically significant interactions between any of the gene variants and alcohol consumption in relation to the various outcomes.Conclusions: In this Caucasian population sample, we found evidence to support that genetic variation in ethanol metabolism may influence drinking habits, but no statistically significant gene-environment interactions. More large-scale epidemiologic studies are needed to confirm theses results and to further investigate genetic susceptibility to the effects of alcohol drinking.