Prognosis of older patients with acute myeloid leukemia receiving either induction or noncurative treatment:: a single-center retrospective study
Prognosis of older patients with acute myeloid leukemia receiving either induction or noncurative treatment:: a single-center retrospective study
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DOI：
10.1007/s00277-003-0650-0
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发表时间：
2003-07-01
影响因子：
3.5
通讯作者：
Lübbert, M
中科院分区：
文献类型：
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作者：
Behringer, B;Pitako, JA;Lübbert, M
由于很少有研究关注高龄急性髓性白血病（AML）患者的预后因素，因此对138例年龄>55岁（中位年龄：67岁，范围：56-89岁）的连续AML患者进行了回顾性分析，这些患者在8年内在单一中心诊断：69%患有新发AML，31%患有继发性AML; 67%的患者进行了核型分析。在这些患者中，73例（53%）接受了标准诱导治疗方案，65例（47%）仅接受了姑息治疗。对以下因素对总生存期（OS）的影响进行了单因素和多因素分析：性别、年龄大于或等于vs
Since few studies focus on prognostic factors in unselected elderly acute myeloid leukemia (AML) patients, a retrospective analysis of 138 consecutive patients aged >55 years (median age: 67, range: 56-89) with AML diagnosed at a single center over an 8-year period was performed: 69% had de novo AML and 31% secondary (s) AML; 67% of the patients were karyotyped. Of the patients, 73 (53%) were treated with standard induction therapy protocols and 65 (47%) received palliative treatment only. Univariate and multivariate analyses of the effects of the following factors on overall survival (OS) were performed: sex, age greater than or equal to vs