Cognitive impairment in euthymic bioplar patients:: implications for clinical and functional outcome
Cognitive impairment in euthymic bioplar patients:: implications for clinical and functional outcome
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DOI：
10.1111/j.1399-5618.2004.00111.x
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发表时间：
2004-06-01
影响因子：
5.4
通讯作者：
Salamero, M
中科院分区：
文献类型：
--
作者：
Martínez-Arán, A;Vieta, E;Salamero, M
目的：双相情感障碍的认知障碍可能是该疾病的一个稳定特征，尽管在缓解期存在的功能障碍存在差异。本研究的目的是确定与健康对照相比，优生双相患者是否会表现出语言学习、记忆和执行功能的损害。其次，确定临床数据与神经心理表现之间是否存在关系。方法：对40例常郁双相患者与30例健康对照者进行了一系列的神经心理测试，评估了预估的病前智商、注意力。语言学习和记忆，以及额叶执行功能。控制亚证症状的影响。结果：在控制亚临床症状的影响后，缓解的双相患者在记忆和执行功能的几个测量中比对照组表现更差。年龄和病前智商言语记忆障碍与功能评分的整体评估、病程的延长、躁狂发作次数的增加以及先前的精神病症状有关。结论：在控制亚综合征性抑郁症状的影响后，结果提供了常郁双相患者存在神经心理障碍的证据。表明言语记忆和执行功能障碍。认知障碍似乎与较差的临床病程和较差的功能预后有关。
Objective: Cognitive impairment in bipolar disorder may be a stable characteristic of the illness, although discrepancies have emerged with regard to what dysfunctions remain during remission periods. The aim of this study was to ascertain whether euthymic bipolar patients would show impairment in verbal learning and memory and in executive functions compared with healthy controls. Secondly, to establish if there was a relationship between clinical data and neuropsychological performance.Methods: Forty euthymic bipolar patients were compared with 30 healthy controls through a battery of neuropsychological tests assessing estimated premorbid IQ, attention. verbal learning and memory, and frontal executive functioning. The effect of subsyndromal symptomatology was controlled.Results: Remitted bipolar patients performed worse than controls in several measures of memory and executive function, after controlling for the effect of subclinical symptomatology. age and premorbid IQ. Verbal memory impairment was related to global assessment of function scores, as well as to a longer duration of illness, a higher number of manic episodes, and prior psychotic symptoms.Conclusions: Results provide evidence of neuropsychological impairment in euthymic bipolar patients, after controlling for the effect of subsyndromal depressive symptoms. suggesting verbal memory and executive dysfunctions. Cognitive impairment seems to be related to a worse clinical course and poor functional outcome.