A review of cutaneous anthrax and its outcome.
A review of cutaneous anthrax and its outcome.
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DOI：
10.1016/j.jiph.2010.07.004
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发表时间：
2010-01-01
影响因子：
6.7
通讯作者：
Alp, Emine
中科院分区：
文献类型：
--
作者：
Doganay, Mehmet;Metan, Gokhan;Alp, Emine
炭疽病在世界上一些国家仍是一种地方病，在西方国家已成为一种重新出现的疾病，最近又有故意爆发。本研究的目的是回顾我们的临床经验与皮肤炭疽病例。从病人的档案，疾病的传播，临床表现和感染的严重程度，治疗和病人的结果进行了记录。近7年共确诊皮肤炭疽22例。其中重度皮肤炭疽10例，轻度皮肤炭疽10例，中毒性休克2例。潜伏期为1至17天。重症皮肤炭疽病例的主要临床特征是发热、出血性大疱性病变，周围有广泛的红斑和水肿，以及白细胞增多。中毒性休克2例，收缩压降低，精神淡漠，有中毒样表现，白细胞增多，低白蛋白血症，低钠血症。15例使用青霉素G，4例使用阿莫西林，3例使用其他抗生素，持续3-10天。4例皮损遗留深部组织瘢痕，行植皮术。在流行地区和西方国家工作的医生应该了解炭疽的所有临床形式。
Anthrax is still an endemic disease in some countries in the world and has become a re-emerging disease in western countries with recent intentional outbreak. The aim of this study was to review our clinical experience with cutaneous anthrax cases. From the patient's files, transmission of the diseases, clinical findings and severity of infection, treatment and outcome of patients were recorded. Twenty-two cases were diagnosed as cutaneous anthrax in the last 7 years. Of these cases, 10 cases were severe form of cutaneous anthrax, 10 cases were mild form and 2 cases were toxemic shock due to cutaneous anthrax. The incubation period was between 1 and 17 days. The main clinical characteristics of the cases with severe cutaneous anthrax were fever, hemorrhagic bullous lesions surrounded by an extensive erythema and edema, and leukocytosis. Two cases with toxemic shock had low systolic blood pressure, apathy and toxemic appearance, leukocytosis, hypoalbuminemia & hyponatremia. Penicillin G was given in 15 cases, amoxicillin in 4 and other antibiotics in 3 cases for 3-10 days. Skin lesion left deep tissue scar in 4 cases and were grafted. Physicians working in endemic areas and also in western countries should be aware of all clinical forms of anthrax.