Brain MRI with laser‐polarized 129xe
Brain MRI with laser‐polarized 129xe
复制标题
激光偏振 129xe 脑部 MRI
DOI：
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发表时间：
1997
影响因子：
3.3
通讯作者：
T. Chupp
中科院分区：
文献类型：
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作者：
S. Swanson;M. Rosen;B. Agranoff;K. Coulter;R. Welsh;T. Chupp
证明了在小动物模型中使用激光偏振129进行脑MRI的可行性。将天然丰富的129极化并引入Sprague-道利大鼠的肺中。极化的氙气溶解在血液中，并被输送到大脑，在那里它积聚在脑组织中。光谱研究显示，相对于气相共振，头部在194.5 ppm处存在单一的、占主导地位的组织相核磁共振。通过2D化学位移成像，使用98 μl体素获得大鼠头部中129 Xe的图像，并显示氙定位于大脑。这项工作确定了气相中产生的核极化在运输到大脑中可以成像的过程中幸存下来。增加极化和129 mmHg的输送量将允许临床测量局部脑血流量。
The feasibility of brain MRI with laser‐polarized 129Xe in a small animal model is demonstrated. Naturally abundant 129Xe is polarized and introduced into the lungs of Sprague‐Dawley rats. Polarized xenon gas dissolves in the blood and is transported to the brain where it accumulates in brain tissue. Spectroscopic studies reveal a single, dominant, tissue‐phase NMR resonance in the head at 194.5 ppm relative to the gas phase resonance. Images of 129Xe in the rat head were obtained with 98‐μl voxels by 2D chemical shift imaging and show that xenon is localized to the brain. This work establishes that nuclear polarization produced in the gas phases survives transport to the brain where it may be imaged. Increases in polarization and delivered volume of 129Xe will allow clinical measurements of regional cerebral blood flow.
影响因子：
19.7
作者：
MacFall, JR;Charles, HC;Ravin, CE
通讯作者：
Ravin, CE