Analysis and some chemical properties of MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone), the potent drinking water mutagen
Analysis and some chemical properties of MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone), the potent drinking water mutagen
复制标题
强效饮用水诱变剂 MX（3-氯-4-（二氯甲基）-5-羟基-2(5H)-呋喃酮）的分析和一些化学性质
DOI：
10.1007/bf00321774
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
S. Lötjönen
中科院分区：
文献类型：
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作者：
T. Vartiainen;K. Heiskanen;S. Lötjönen
摘要强效饮用水诱变剂 3-氯-4-(二氯甲基)-5-羟基-2(5H)-呋喃酮 (MX) 在水中的溶解度（pH 值 2、5、7 和 9 时分别为 50.8、44.7、43.7 和 51.0 mg/ml）仅轻微依赖于 pH，与辛醇/水分配相反（log Pow 1.13， pH 2、5、7 和 9 时分别为 0.84、-0.44 和 -1.02）。 MX 在乙酸乙酯和酸性水溶液中稳定。从水或尿样中分离时，MX 的回收率约为 100%，但在甲基化过程中，MX 的回收率约为 73-82%。测试 MX 的替代分离和衍生方法并未给出更好的结果。
SummaryThe solubility of the potent drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in water (50.8, 44.7, 43.7, and 51.0 mg/ml at pH values 2, 5, 7, and 9, respectively) was only slightly dependent on pH, on the contrary to octanol/water partition (log Pow 1.13, 0.84, −0.44, and −1.02 at pH 2, 5, 7, and 9, respectively). MX was stable in ethyl acetate and acidic water solutions. The recovery of MX during isolation from water or urine samples was about 100% but about 73–82% in the methylation process. The alternative isolation and derivatization methods tested for MX did not give better results.