Reduced graphene oxide/platinum nanoparticles/nafion nanocomposite as a novel 2D electrochemical sensor for voltammetric determination of aliskiren
Reduced graphene oxide/platinum nanoparticles/nafion nanocomposite as a novel 2D electrochemical sensor for voltammetric determination of aliskiren
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DOI：
10.1039/c7nj00569e
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发表时间：
2017-12-21
影响因子：
3.3
通讯作者：
Erk, Nevin
中科院分区：
文献类型：
--
作者：
Ates, Ali Kemal;Er, Engin;Erk, Nevin
本研究描述了一种灵敏的和选择性的石墨烯为基础的电化学纳米传感器检测阿利吉仑（ALS）的制造。这是第一项研究，其中电化学氧化和测定ALS的循环伏安法（CV）和吸附溶出微分脉冲伏安法（AdsDPV）使用2D纳米复合电极修饰还原氧化石墨烯/铂纳米粒子/nafion（rGO/PtNPs/NFN/GCE）。采用一步化学还原法，以氧化石墨烯（GO）和铂盐为原料，直接合成了rGO/PtNP纳米复合材料。采用X射线衍射（XRD）和透射电子显微镜（TEM）对合成的rGO/PtNPs进行表征。所开发的传感器表现出优异的电催化活性（即移动电位从1225到1059 mV）对ALS的氧化。在0.045-0.45 μ M和0.45-2.70 μ M两个浓度范围内，ALS的伏安响应与浓度呈良好的线性关系，检出限为8.2 nM。通过测定人血浆中ALS，回收率为97.0%，证明了所提出的传感器的分析适用性。结果强烈表明，所提出的传感器可能是有前途的作为一种替代的分析方法，在临床样品中的ALS的常规分析。
This study describes the fabrication of a sensitive and selective graphene-based electrochemical nanosensor for the detection of aliskiren (ALS). It is the first research study where the electrochemical oxidation and determination of ALS were investigated by cyclic voltammetry (CV) and adsorptive stripping differential pulse voltammetry (AdsDPV) using a 2D nanocomposite electrode modified with reduced graphene oxide/platinum nanoparticles/nafion (rGO/PtNPs/NFN/GCE). An rGO/PtNP nanocomposite was synthesized directly from graphene oxide (GO) and platinum salt using a single-step chemical reduction method. The synthesized rGO/PtNPs were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The developed sensor exhibited excellent electrocatalytic activity (i.e. shifting the potential from 1225 to 1059 mV) towards the oxidation of ALS. The voltammetric responses of ALS presented a good linearity with an increase in concentration within two concentration ranges of 0.045-0.45 mu M and 0.45-2.70 mu M with a low detection limit of 8.2 nM. The analytical applicability of the proposed sensor was demonstrated by determining ALS with the recovery result of 97.0% in human blood plasma. The results strongly suggested that the proposed sensor could be promising as an alternative analytical approach for routine analysis of ALS in clinical samples.