Decreased bone mass and strength in ovariectomized cynomolgus monkeys (Macaca fascicularis).
Decreased bone mass and strength in ovariectomized cynomolgus monkeys (Macaca fascicularis).
复制标题
切除卵巢的食蟹猴（食蟹猴）的骨量和强度降低。
DOI：
10.1007/s002239900227
复制
发表时间：
1997
影响因子：
4.2
通讯作者：
Lees,CJ
中科院分区：
文献类型：
--
作者：
Jerome,CP;Turner,CH;Lees,CJ
现在必须在表现出骨重建的大型动物物种中测试预防或治疗骨质疏松症的药物。卵巢切除的非人灵长类动物提供了一个这样的模型，它们持续发生骨质减少，伴有高骨转换率。本研究的目的是进一步表征该模型，特别是确定卵巢切除术对椎骨和股骨颈骨强度的影响。在19只假卵巢切除（SHAM）和18只卵巢切除（OVX）的9岁以上家养食蟹猴中进行脊柱骨量和骨转换血清标志物的纵向评价。相对于基线值和SHAM对照，OVX猴的骨丢失。血清骨转换标志物增加OVX。72周后，OVX动物的椎体压缩强度和股骨颈断裂强度均显著低于SHAM动物。与绝经后女性一样，卵巢切除的食蟹猴出现骨丢失加速、骨转换增加和骨强度降低，并为预防或治疗骨质疏松症的药物的疗效研究提供了合适的大型动物模型。
Agents for prevention or treatment of osteoporosis must now be tested in a large animal species that exhibits bone remodeling. Ovariectomized, nonhuman primates provide one such model, and they consistently develop osteopenia accompanied by high bone turnover rates. The goal of this study was to further characterize this model, and particularly to determine the effect of ovariectomy on bone strength in vertebrae and femoral necks. Longitudinal evaluations of spinal bone mass and serum markers of bone turnover were performed in 19 sham-ovariectomized (SHAM) and 18 ovariectomized (OVX), domestically reared cynomolgus monkeys, aged >9 years. OVX monkeys lost bone relative to both baseline values and SHAM controls. Serum markers of bone turnover were increased by OVX. After 72 weeks, both vertebral bone compressive strength and femoral neck breaking strength were significantly decreased in OVX animals compared with SHAM. Ovariectomized cynomolgus monkeys, like postmenopausal women, develop accelerated bone loss, increased bone turnover, and reduced bone strength, and provide a suitable large animal model for efficacy studies with agents for prevention or treatment of osteoporosis.