Maternal Care Influences Hippocampal N-Methyl-D-Aspartate Receptor Function and Dynamic Regulation by Corticosterone in Adulthood
Maternal Care Influences Hippocampal N-Methyl-D-Aspartate Receptor Function and Dynamic Regulation by Corticosterone in Adulthood
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DOI：
10.1016/j.biopsych.2012.03.016
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发表时间：
2012-09-15
影响因子：
10.6
通讯作者：
Wong, Tak Pan
中科院分区：
文献类型：
--
作者：
Bagot, Rosemary C.;Tse, Yiu Chung;Wong, Tak Pan
背景资料：大鼠母体护理的变化与后代海马发育和突触可塑性的显著差异有关。产妇护理也影响垂体-肾上腺应激反应和皮质酮（CORT）调节海马可塑性。N-甲基-D-天冬氨酸受体（NMDAR）调节突触可塑性，并且NMDAR功能受应激和CORT调节。我们假设改变的NMDAR功能是母体和应激对海马突触可塑性的影响的相互作用的基础。方法：我们使用电生理学和蛋白质印迹来检查NMDAR突触功能/表达和NMDAR依赖的长时程增强（LTP）在不同的幼崽舔/梳理（LG）频率（即，结果：成年低LG子代海马齿状回（DG）的基础NMDAR突触功能增强。突触表达的NMDAR，但不是α-氨基-3-羟基-甲基-4-异恶唑丙酸受体也增加。2015年10月10日，《中国日报》（
Background: Variations in maternal care in the rat associate with robust differences in hippocampal development and synaptic plasticity in the offspring. Maternal care also influences pituitary-adrenal stress responses and corticosterone (CORT) regulation of hippocampal plasticity. N-methyl-D-aspartate receptors (NMDAR) regulate synaptic plasticity, and NMDAR function is modulated by stress and CORT. We hypothesized that altered NMDAR function underlies the interaction of maternal and stress effects on hippocampal synaptic plasticity.Methods: We used electrophysiology and western blot to examine NMDAR synaptic function/expression and NMDAR-dependent long-term potentiation (LTP) in adult offspring of mothers that varied in the frequency of pup licking/grooming (LG) (i.e., High or Low LG).Results: Basal NMDAR synaptic function was enhanced in the hippocampal dentate gyrus (DG) of adult Low LG offspring. Synaptic expression of NMDAR but not alpha-amino-3-hydroxy-methyl-4-isoxazole propionic acid receptors was also increased. Stress level CORT (100 nmol/L) rapidly (