Putative environmental-endocrine disruptors and obesity: a review.
Putative environmental-endocrine disruptors and obesity: a review.
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推定的环境 - 内分泌破坏者和肥胖症：评论。
DOI：
10.1097/med.0b013e32830ce95c
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Allison DB
中科院分区：
文献类型：
--
作者：
Elobeid MA;Allison DB
在过去的几十年里，肥胖的患病率大幅增加。最近的证据表明，干扰内分泌的化学品，例如卤代芳烃，可能会扰乱内源性激素调节，并改变与体重动态平衡有关的其他机制，从而可能导致脂肪组织体积增加，导致体重增加。来自工业生产过程的合成化学品被怀疑起了推波助澜的作用。然而，在大约70，000种记录在案的合成化学品中，很少有人被检查以确定它们对内分泌系统的影响。本研究审查了以前的实验室，流行病学和实验研究结果。数据表明，环境中的内分泌干扰物的迁移，并开始编目其对肥胖症的影响。我们提出了这些化学物质，其作用机制和肥胖症流行之间的关系。内分泌干扰物可能通过改变生理控制机制对人类和环境健康产生不利影响。众所周知，肥胖症会增加医疗费用，降低生活质量和寿命，它可能会随着内分泌干扰物的暴露而增加。这值得科学家和公共卫生官员关注，并需要在这一领域进行更多的积极研究。
There has been a substantial increase in the prevalence of obesity in the last several decades. Recent evidence suggests that endocrine disrupting chemicals, e.g. halogenated aromatic hydrocarbons, may cause perturbations in endogenous hormonal regulation and alter other mechanisms involved in weight homeostasis, which may lead to weight gain by increased volume of adipose tissue. Synthetic chemicals derived from industrial processes are suspected to play a contributory role. Yet of the approximately 70,000 documented synthetic chemicals, few have been examined to determine their effects on the endocrine system. The present study examines prior laboratory, epidemiological and experimental research findings. Data demonstrate migration of endocrine disruptors in the environment and are beginning to catalogue their effects on adiposity. We present postulated relationships between these chemicals, their mechanisms of action, and the obesity epidemic. Endocrine disruptors may adversely impact human and environmental health by altering physiological control mechanism. Obesity, which is known to increase medical costs and reduce quality and length of life, may be increasing as a function of endocrine disruptor exposure. This merits concern among scientists and public health officials and warrants additional vigorous research in this area.