Heparin and human lipid metabolism.
Heparin and human lipid metabolism.
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DOI：
10.1016/s0140-6736(69)91801-7
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发表时间：
1969-05
期刊：
影响因子：
168.9
通讯作者：
D. Rutstein;W. Castelli;R. Nickerson
中科院分区：
文献类型：
--
作者：
D. Rutstein;W. Castelli;R. Nickerson
在脂肪或碳水化合物试验餐前或长时间禁食前，以及静脉注射肝素前后，从健康志愿者中采集血样。对血清进行生化分析，并在组织培养模型中进行测试，旨在评估脂质的细胞内沉积。肝素导致脂质沉积增加，这可能与非酯化脂肪酸（N.E.F.A.）的血清水平增加相关，但甘油三酯、胆固醇和磷脂的浓度降低。这种肝素诱导的脂质沉积在高胆固醇血症患者中更为明显。细胞内脂质沉积是可逆的。气液色谱表明，脂肪酸趋于饱和，因为它们被纳入组织培养细胞。结合其他已发表的证据，高N.E.F.A.水平与心律失常和心肌梗死患者的死亡有关，这些结果表明在这种情况下使用肝素可能存在危险，需要进一步研究N.E.F.A.在冠心病和对照试验的价值肝素在治疗和预防急性心肌梗死。
Blood-samples were collected from healthy volunteers before a test-meal of fat or carbohydrate or before a prolonged fast, and then before and after the intravenous injection of heparin. The serum was analysed biochemically and was tested in a tissue-culture model designed to assess the intracellular deposition of lipids. Heparin led to increased lipid deposition, and this could be correlated with an increase in serum-levels of non-esterified fatty acids (N.E.F.A.), but not with the decreased concentration of triglycerides, cholesterol, and phospholipids. This heparin-induced lipid deposition was more striking in hypercholesterolæmic individuals. Intracellular lipid deposition is reversible. Gas-liquid chromotography suggested that fatty acids tend to become saturated as they are incorporated within the tissue-culture cells. Taken together with other published evidence that high N.E.F.A. levels are associated with arrhythmias and death in patients with myocardial infarction, these results point to a possible danger in the use of heparin in such cases, and to the need for further work on the role of N.E.F.A. in coronary heart-disease and for controlled trials of the value of heparin in the treatment and prevention of acute myocardial infarction.