CONTROL OF NEURONAL FATE BY THE DROSOPHILA SEGMENTATION GENE EVEN-SKIPPED
CONTROL OF NEURONAL FATE BY THE DROSOPHILA SEGMENTATION GENE EVEN-SKIPPED
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DOI：
10.1038/333376a0
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发表时间：
1988-05-26
期刊：
影响因子：
64.8
通讯作者：
GOODMAN, CS
中科院分区：
文献类型：
--
作者：
DOE, CQ;SMOUSE, D;GOODMAN, CS
中枢神经系统（CNS）包含显著多样性的细胞类型。产生这种神经元多样性的分子基础知之甚少。然而，在早期果蝇胚胎发生过程中控制体节和体节同一性的调控基因已经有了很多了解1，2。有趣的是，果蝇中的大多数分节基因和同源异型基因，以及它们的许多脊椎动物同源基因，在神经系统发育过程中表达（例如，参考文献3）。这些基因是否参与了神经发生过程中单个神经元的身份的确定，就像它们在分割过程中确定细胞的身份一样？我们以前描述了中枢神经系统的表达分割genefushi tarazu（ftz），并表明thatftzCNS表达参与确定一个确定的神经元3。在这里，我们展示了另一个分割基因，even-skipped（eve），在一个不同但重叠的神经元子集中表达。在神经发生过程中，温度敏感的蛋白质失活改变了其中两个神经元的命运。我们的研究结果表明，核蛋白产物的eve和ftz分割基因的组成部分的机制控制细胞的命运在神经元的发展。
The central nervous system (CNS) contains a remarkable diversity of cell types. The molecular basis for generating this neuronal diversity is poorly understood. Much is known, however, about the regulatory genes which control segmentation and segment identity during earlyDrosophilaembryogenesis1,2. Interestingly, most of the segmentation and homoeotic genes inDrosophila, as well as many of their vertebrate homologues, are expressed during the development of the nervous system (for example, ref. 3). Are these genes involved in specifying the identity of individual neurons during neurogenesis, just as they specify the identity of cells during segmentation? We previously described the CNS expression of the segmentation genefushi tarazu(ftz) and showed thatftzCNS expression is involved in the determination of an identified neuron3. Here we show that another segmentation gene,even-skipped(eve), is expressed in a different but overlapping subset of neurons. Temperature-sensitive inactivation of theeveprotein during neurogenesis alters the fate of two of these neurons. Our results indicate that the nuclear protein products of theeveandftzsegmentation genes are components of the mechanism controlling cell fate during neuronal development.