Reactive arthritis following an outbreak of Salmonella typhimurium phage type 193 infection
Reactive arthritis following an outbreak of Salmonella typhimurium phage type 193 infection
复制标题
DOI：
10.1136/ard.61.3.264
复制
发表时间：
2002-03-01
影响因子：
27.4
通讯作者：
Leirisalo-Repo, M
中科院分区：
文献类型：
--
作者：
Hannu, T;Mattila, L;Leirisalo-Repo, M
目的：为了确定的发生和反应性关节炎（ReA）的临床图片后，爆发的沙门氏菌typhimurium.Methods：爆发的鼠伤寒沙门氏菌噬菌体型DT 193发生在芬兰的几个城市在1999年。将一份特别强调肌肉骨骼症状的问卷邮寄给所有78名粪便培养阳性的受试者。根据答案，所有受试者与最近的关节投诉进行了临床检查或通过电话采访。结果：63 78名受试者（81%）返回问卷。在这63例受试者中，5例（8%）符合ReA标准。所有5名ReA受试者均为患有少关节炎或多关节炎的成年人。HLA-B27抗原在四名受试者中的两名中呈阳性。在5名ReA受试者中，有2名急性关节炎的持续时间超过6个月。接受抗微生物药物治疗的受试者发生急性肌肉骨骼症状的频率显著低于未接受此类治疗的受试者（p=0.013）。没有一个与ReA的主题已经收到抗菌药物的联合symptoms.Conclusions发病前：ReA的发生后，鼠伤寒沙门氏菌的爆发是在相同的水平，由于其他沙门氏菌血清型的爆发由我们以前报道，表明ReA的频率后，各种爆发是-10%。早期使用抗微生物药物可以防止肌肉骨骼症状的发展。
Objectives: To determine the occurrence and the clinical picture of reactive arthritis (ReA) following an outbreak of Salmonella typhimurium.Methods: An outbreak of S typhimurium phage type DT 193 occurred in several municipalities in Finland in 1999. A questionnaire which had a specific emphasis on musculoskeletal symptoms was mailed to all 78 subjects with a positive stool culture. Based on the answers, all subjects with recent joint complaints were clinically examined or interviewed by telephone.Results: Sixty three of 78 subjects (81%) returned the questionnaire. Of these 63 subjects, five (8%) fulfilled the criteria for ReA. All the five subjects with ReA were adults with oligo- or polyarthritis. The antigen HLA-B27 was positive in two of the four subjects tested. In two of five subjects with ReA, the duration of acute arthritis was over six months. Subjects who had received antimicrobial drugs developed acute musculoskeletal symptoms significantly (p=0.013) less often than those without such treatment. None of the subjects with ReA had received antimicrobial drugs before the onset of joint symptoms.Conclusions: The occurrence of ReA following an outbreak of S typhimurium was at the same level as in outbreaks due to other salmonella serotypes reported previously by us, indicating that the frequency of ReA after various outbreaks is -10%. Early use of antimicrobial drugs may prevent the development of musculoskeletal symptoms.