Aging of the Cervical Spine in Healthy Volunteers A 10-Year Longitudinal Magnetic Resonance Imaging Study
Aging of the Cervical Spine in Healthy Volunteers A 10-Year Longitudinal Magnetic Resonance Imaging Study
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DOI：
10.1097/brs.0b013e31819c2003
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发表时间：
2009-04-01
期刊：
影响因子：
3
通讯作者：
Takahata, Takeshi
中科院分区：
文献类型：
--
作者：
Okada, Eijiro;Matsumoto, Morio;Takahata, Takeshi
研究设计.前瞻性纵向研究，平均随访期;从1995年至2007年进行了11.7 +/- 0.8年。阐明颈椎的正常老化过程以及椎间盘退变的进展与临床症状发展之间的相关性。颈椎的老化不可避免地发生在任何人身上。对同一个体进行长期的纵向研究是阐明颈椎准确老化过程的必要条件。497个原始队列中的223例受试者（123例男性，100例女性，平均年龄：39.0 ± 15.0，随访率：44.9%）。10年前接受MRI检查的受试者再次接受MRI、神经系统检查和关于颈椎和生活方式相关症状的问卷调查。结果：（1）椎间盘信号减弱，（2）硬膜和脊髓受压，（3）椎间盘后突，（4）椎间隙狭窄，（5）椎间孔狭窄。在189例受试者（81.1%）中观察到退行性病变进展。椎间盘信号强度降低的进展占59.6%，硬膜和脊髓前部受压占61.4%，PDP占70.0%，DSN占26.9%，FS占9.0%。逻辑回归分析显示，老年受试者的PDP、DSN、FS进展发生率较高。任何退行性MR结果与性别、吸烟、饮酒、运动或体重指数之间均无相关性。颈痛、肩关节僵硬和上肢麻木的发生率分别为9.9%、30.0%和4.0%，其中34.1%的患者在10年内出现了1种或多种临床症状。在10年期间，经常观察到MRI上颈椎退变的进展，34%的受试者出现症状。除年龄外，未发现与颈椎退行性变进展相关的因素。
Study Design. Prospective longitudinal study, mean follow-up period; 11.7 +/- 0.8 years was conducted from 1995 to 2007.Objective. To clarify normal aging process of cervical spine and correlation between progression of disc degeneration and development of clinical symptoms.Summary of Background Data. Aging of the cervical spine can inevitably occur in anyone. Long-term longitudinal studies following the same individuals are necessary to elucidate the accurate aging processes of the cervical spine.Methods. Two hundred twenty-three subjects of 497 original cohorts (123 men, 100 women, mean age: 39.0 +/- 15.0, follow-up rate: 44.9%). Subjects, who underwent MRI 10 years ago, underwent another MRI, neurologic examination, and questionnaire survey regarding symptoms related to cervical spine and life style. Following 5 MR findings representing intervertebral disc degeneration were evaluated: (1) decrease in signal intensity of disc, (2) anterior compression of dura and spinal cord, (3) posterior disc protrusion (PDP), (4) disc space narrowing (DSN), and (5) foraminal stenosis (FS).Results. Progression of degenerative findings was observed in 189 subjects (81.1%). Progression of decrease in signal intensity of disc was observed in 59.6%, anterior compression of dura and spinal cord in 61.4%, PDP in 70.0%, DSN in 26.9%, and FS in 9.0%. Logistic regression analysis revealed that incidence of progression of PDP, DSN, FS was higher in elderly subjects. There were no correlations between any degenerative MR findings and sex, smoking, alcohol, sport, or body mass index. Neck pain, shoulder stiffness, and numbness in upper extremities were recognized in 9.9%, 30.0%, and 4.0% of subjects, and 1 or more clinical symptoms have developed in 34.1% during 10 years.Conclusion. Progression of degeneration of cervical spine on MRI was frequently observed during 10-year period, with development of symptoms in 34% of subjects. No factor related to progression of degeneration of cervical spine was identified except for age.