Dietary Inflammatory Potential and Bone Outcomes in Midwestern Post-Menopausal Women.
Dietary Inflammatory Potential and Bone Outcomes in Midwestern Post-Menopausal Women.
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DOI：
10.3390/nu15194277
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发表时间：
2023-10-07
期刊：
影响因子：
5.9
通讯作者：
Hanson C
中科院分区：
文献类型：
--
作者：
Jackson MK;Bilek LD;Waltman NL;Ma J;Hébert JR;Price S;Graeff-Armas L;Poole JA;Mack LR;Hans D;Lyden ER;Hanson C
人们对饮食的潜在炎症及其与骨骼健康的关系知之甚少。这项横断面研究探讨了饮食的炎症潜力与中西部绝经后妇女参加Heartland骨质疏松症预防研究（HOPS）随机对照试验的骨相关结果之间的关联。来自HOPS队列的膳食摄入量用于计算膳食炎症指数（DII®）评分，其经能量调整（E-DIITM）并通过四分位数进行分析。使用ANCOVA评估E-DII与腰椎和髋部骨矿物质密度（BMD）和腰椎骨小梁评分（TBS;骨结构）之间的相关性，并进行成对比较以调整相关混杂因素（年龄、教育、种族/民族、吸烟史、骨质疏松症/骨量减少家族史、BMI、体力活动和钙摄入量）。该队列包括272名女性，主要是白色（89%），受过教育（78%具有大学或更高学历），平均BMI为27 kg/m2，年龄为55岁，E-DII评分为−2.0 ± 1.9（更抗炎）。校正后，E-DII评分与腰椎BMD（p = 0.53）、髋部BMD（p = 0.29）或任何腰椎部位TBS（p > 0.05）均无显著相关性。未来的研究应该在更大，更多样化的队列中检查E-DII评分和骨健康的纵向影响。
Little is known about the inflammatory potential of diet and its relation to bone health. This cross-sectional study examined the association between the inflammatory potential of diet and bone-related outcomes in midwestern, post-menopausal women enrolled in the Heartland Osteoporosis Prevention Study (HOPS) randomized controlled trial. Dietary intake from the HOPS cohort was used to calculate Dietary Inflammatory Index (DII®) scores, which were energy-adjusted (E-DIITM) and analyzed by quartile. The association between E-DII and lumbar and hip bone mineral density (BMD) and lumbar trabecular bone scores (TBS; bone structure) was assessed using ANCOVA, with pairwise comparison to adjust for relevant confounders (age, education, race/ethnicity, smoking history, family history of osteoporosis/osteopenia, BMI, physical activity, and calcium intake). The cohort included 272 women, who were predominately white (89%), educated (78% with college degree or higher), with a mean BMI of 27 kg/m2, age of 55 years, and E-DII score of −2.0 ± 1.9 (more anti-inflammatory). After adjustment, E-DII score was not significantly associated with lumbar spine BMD (p = 0.53), hip BMD (p = 0.29), or TBS at any lumbar location (p > 0.05). Future studies should examine the longitudinal impact of E-DII scores and bone health in larger, more diverse cohorts.