Characterization of parafoveal hemodynamics associated with diabetic retinopathy with adaptive optics scanning laser ophthalmoscopy and computational fluid dynamics.
Characterization of parafoveal hemodynamics associated with diabetic retinopathy with adaptive optics scanning laser ophthalmoscopy and computational fluid dynamics.
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DOI：
10.1109/embc.2015.7320266
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Sun JK
中科院分区：
文献类型：
--
作者：
Bernabeu MO;Yang Lu;Lammer J;Aiello LP;Coveney PV;Sun JK
糖尿病视网膜病变（DR）仍然是美国和世界其他发达国家工作年龄成年人视力丧失的主要原因。先前的研究已经报道了糖尿病眼的血流动力学变化，其先于视网膜微血管的临床明显病理改变。迫切需要新的方法，以更好地了解这些早期的血液动力学变化，发生在DR。在目前的研究中，我们提出了一种非侵入性的方法，用于评估周围的中央凹（一个区域的眼睛的视力至关重要）的血液动力学。所提出的方法结合了自适应光学扫描激光检眼镜和计算流体动力学建模和仿真。我们的初步研究结果表明，这里提出的技术是可行的，在眼睛的中心凹区域的血流动力学的评估，而且，它是能够检测眼睛之间的血流动力学的差异，可能与DR状态。我们相信，所提出的方法有可能成为一个有用的工具，在临床背景下，人类视网膜血流动力学的评价。
Diabetic retinopathy (DR) remains the leading cause of visual loss in working age adults in the United States and other developed countries worldwide. Previous studies have reported hemodynamic changes in the diabetic eye that precede clinically evident pathological alterations of the retinal microvasculature. There exists a pressing need for new methods to allow greater understanding of these early hemodynamic changes that occur in DR. In the current study, we propose a noninvasive method for the assessment of hemodynamics around the fovea (a region of the eye of paramount importance for vision). The proposed methodology combines adaptive optics scanning laser ophthalmoscopy and computational fluid dynamics modeling and simulation. Our preliminary results indicate that the technique presented here is feasible for the assessment of hemodynamics in the foveal region of the eye and, moreover, that it is capable of detecting differences in hemodynamics between eyes that may be associated with DR status. We believe that the proposed methodology has the potential to become a useful tool for the evaluation of human retinal hemodynamics in a clinical context.