Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons
Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons
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DOI：
10.1126/science.291.5507.1279
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发表时间：
2001-02-16
期刊：
影响因子：
56.9
通讯作者：
Koonin, EV
中科院分区：
文献类型：
--
作者：
Aravind, L;Dixit, VM;Koonin, EV
将近期（近乎）完成的人类基因组所编码的蛋白质与果蝇和线虫基因组所编码的蛋白质进行比较，结果显示，就所涉及的蛋白质数量及其结构域构成而言，脊椎动物中细胞凋亡分子机制的复杂性大幅增加。细胞凋亡系统的一些组成部分为人类和果蝇所共有，而线虫则没有，这似乎支持了在动物进化过程中存在一个体腔动物分支的观点。在放线菌和蓝细菌中检测到了大量的细胞凋亡蛋白质结构域，这表明水平基因转移对细胞凋亡的早期进化有重要贡献。
A comparison of the proteins encoded in the recently (nearly) completed human genome to those from the fly and nematode genomes reveals a major increase in the complexity of the apoptotic molecular machinery in vertebrates, in terms of both the number of proteins involved and their domain architecture. Several components of the apoptotic system are shared by humans and flies, to the exclusion of nematodes, which seems to support the existence of a coelomate clade in animal evolution. A considerable repertoire of apoptotic protein domains was detected in Actinomycetes and Cyanobacteria, which suggests a major contribution of horizontal gene transfer to the early evolution of apoptosis.