The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems.
The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems.
复制标题
DOI：
10.1093/ecam/nem007
复制
发表时间：
2008-03
期刊：
影响因子：
--
通讯作者：
Lombardo G
中科院分区：
文献类型：
--
作者：
Firenzuoli F;Gori L;Lombardo G
巴西蘑菇（Agaricus blazei Murrill，ABM）在巴西被称为“Cogumelo do Sol”，在日本被称为“Himematsutake”，是一种原产于巴西的蘑菇，在日本被广泛种植用于其药用用途，因此它现在被认为是最重要的食用和食用-药用生物技术物种之一。传统上用于治疗动脉粥样硬化、肝炎、高脂血症、糖尿病、皮炎和癌症等许多常见疾病。在体外和体内ABM已显示出免疫调节和抗突变的特性，虽然生物学途径和化学物质参与其药理活性仍然不清楚。多糖植物复合物被认为是负责其免疫刺激和抗肿瘤特性，可能通过调理生化途径。临床研究是积极的确认，但我们仍处于起步阶段，特别是关于蘑菇碱的含量存在令人困惑的担忧。阿甘丁是一种众所周知的致癌和有毒物质，必须进行全面和充分的评估。
Agaricus blazei Murrill (ABM) popularly known as ‘Cogumelo do Sol’ in Brazil, or ‘Himematsutake’ in Japan, is a mushroom native to Brazil, and widely cultivated in Japan for its medicinal uses, so it is now considered as one of the most important edible and culinary-medicinal biotechnological species. It was traditionally used to treat many common diseases like atherosclerosis, hepatitis, hyperlipidemia, diabetes, dermatitis and cancer. In vitro and in vivo ABM has shown immunomodulatory and antimutagenic properties, although the biological pathways and chemical substances involved in its pharmacological activities are still not clear. The polysaccharides phytocomplex is thought to be responsible for its immunostimulant and antitumor properties, probably through an opsonizing biochemical pathway. Clinical studies are positive confirmations, but we are still at the beginning, and there are perplexing concerns especially relative to the content of agaritine. Argantine is a well-known carcinogenic and toxic substance in animals, that must be completely and fully evaluated.