Complementary Metal-Oxide-Semiconductor Integrated Carbon Nanotube Arrays: Toward Wide-Bandwidth Single-Molecule Sensing Systems.
Complementary Metal-Oxide-Semiconductor Integrated Carbon Nanotube Arrays: Toward Wide-Bandwidth Single-Molecule Sensing Systems.
复制标题
DOI：
10.1021/acs.nanolett.6b00319
复制
发表时间：
2016-04-13
期刊：
影响因子：
10.8
通讯作者：
Shepard KL
中科院分区：
文献类型：
--
作者：
Warren SB;Vernick S;Romano E;Shepard KL
人们对实现无标记、电子化和单分子的基因组分子诊断平台有着浓厚的兴趣。单分子场效应晶体管(SmFET)是一种很有吸引力的换能器，它能够探测单个电子电荷，并由点功能化的裸栅一维碳纳米管场效应器件实现。在这项工作中，smFET被直接集成到定制的互补金属氧化物半导体(CMOS)芯片上，从而产生了多达6000个设备的阵列，提供1-MHz的测量带宽。在这些高带宽测量能力的首次开发中，通过电化学氧化设备的点功能化以微秒的时间分辨率被观察到，揭示了具有可分辨散射特征的复杂反应路径。在某些氧化设备中检测到高速随机电报噪声，进一步说明了该平台的测量能力。
There is strong interest in realizing genomic molecular diagnostic platforms that are label-free, electronic, and single-molecule. One attractive transducer for such efforts is the single-molecule field-effect transistor (smFET), capable of detecting a single electronic charge and realized with a point-functionalized exposed-gate one-dimensional carbon nanotube field-effect device. In this work, smFETs are integrated directly onto a custom complementary metal-oxide-semiconductor (CMOS) chip, resulting in an array of up to 6000 devices delivering a measurement bandwidth of 1-MHz. In a first exploitation of these high-bandwidth measurement capabilities, point functionalization through electrochemical oxidation of the devices is observed with microsecond temporal resolution, revealing complex reaction pathways with resolvable scattering signatures. High-rate random telegraph noise is detected in certain oxidized devices, further illustrating the measurement capabilities of the platform.