Pan-vertebrate conserved non-coding sequences associated with developmental regulation
Pan-vertebrate conserved non-coding sequences associated with developmental regulation
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DOI：
10.1093/bfgp/elp033
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发表时间：
2009-07-01
期刊：
影响因子：
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通讯作者：
Elgar, Greg
中科院分区：
文献类型：
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作者：
Elgar, Greg
虽然编码序列很容易通过计算方法在脊椎动物基因组中识别，但传统上识别非编码调控序列要困难得多，因为它们的大小很小，而且通常基因组之间的序列同源性很低。然而，在整个脊椎动物辐射过程中，一小部分非编码序列是非常保守的。这篇综述将着眼于这些序列的具体性质，它们是如何从功能上被识别和分析的，以及在寻找和理解其中编码的潜在语言和语法方面的最新进展。我还将讨论这些元素的进化，并研究它们在疾病中出现的和可能的作用。这些分析一起开始解开保守的非编码区如何在分子水平上发挥作用。
Whilst coding sequences are readily recognised in vertebrate genomes using computational approaches, the identification of non-coding regulatory sequences has traditionally been much more difficult, due to their small size and, as a general rule, low sequence homology between genomes. Nevertheless, a small proportion of non-coding sequence is very highly conserved across the entire vertebrate radiation. This review will look at the specific properties of these sequences, how they have been identified and assayed functionally, and current progress in the quest to identify and understand the underlying language and grammar encoded within them. I will also discuss the evolution of these elements, and examine their emerging and likely roles in disease. Together these analyses are starting to unravel how conserved non-coding regions function at the molecular level.